Neoplasias Mieloproliferativas

En esta obra se recoge una selección de ponencias congresuales de destacados oncólogos, especialistas en síndromes mieloroliferativos clásicos Phi negativos. Reúne capítulos en inglés y en español.

Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B, Volume 366 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Sections cover Genetic and Sex predisposition to MPN, Transcriptional configurations of Myeloproliferative Neoplasms, Inhibitors and therapeutic targets of MPN, Mutational landscape of blast-phase myeloproliferative neoplasm (MPN-BP) and antecedent MPN, and Lessons from Mouse model of MPN, Lab tests for MPN. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists from international sources Offers a wide range of perspectives on specific subjects

This new series on the treatment of cancer is sponsored by the VICe. The editors and authors feel strongly that more standardiza tion is needed on a worldwide basis in cancer therapy. This, of course, is only possible if experts from all countries subscribe to a joint policy of making their treatment designs available to practising oncologists all over the world. Current Treatment of Cancer will discuss all the equipment and methods now in use in cancer therapy. It will cover all types of cancer, thus providing the reader with comprehensive information on cancer management. In recent decades there has been a tremendous improvement in the treatment of cancer, and there is hope for even further success in this fight. We are convinced that this series will help us to make a concerted response to the challenge of cancer. VICC Treatment and Rehabilitation Programme Ismail Elsebai Chairman VII Preface During the past two decades we have witnessed an exciting evolution in the un derstanding and management of hematologic malignancies. The number of drugs available 20 years ago for the treatment of acute leukemia was so small that the disease in children and in adults could be discussed within one chapter. Since then, rapid progress has been made in the management of childhood leukemia, making for a much better prognosis. Over the past 10 years we have seen the same developments in respect of leukemia in adults.

This atlas presents not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies. An expert hematopathologist here provides a valuable resource to understand, use, or interpret one or more of these diagnostic modalities with confidence. This new edition has a compact format with up-to-date information - especially on genetic aspects - and will be an indispensable reference for all professionals in the specialty. *Provides an unrivalled visual resource for differential diagnosis in neoplastic hematopathology *Enables specialist and trainee oncologists and pathologists alike to understand, use, and interpret diagnostic modalities with confidence *Supplies quick access to information via tables, algorithms, and composite figures

Introduction The understanding of the genetic, epigenetic, immuno- well as for practicing hematologists or oncologists. logical and biological causes of myeloproliferative dis- Each chapter follows a similar architecture and leads orders has substantially improved in the last few years. through epidemiology, genetic and molecular causes, Together with refined tools in pathology, the successful hematological and clinical findings, prognostic factors establishment of mouse models mimicking at least some and current treatment approaches of the diseases. of the myeloproliferative disorders, and murine models Effort has been made to point out the evolving field of novel drugs in this arena but simultaneously diff- allowing to carefully dissect the role of mutations and gene dosage effects of, for example JAK2, this has led to entiate between standard and experimental treatment ever increasing numbers of modified classification approaches. schemes. It is therefore important for the heamtologist Together with the co-editors and all the authors of or oncologist to keep up with this rapid change in classi- the various chapters I hope that the readers of the book fication language, the upcoming of new entities or differ- will enjoy reading and benefit from the information entiation between, or subclassification of, rare diseases provided.

Durante más de 65 años, este éxito de ventas de los doctores Barbara Bain, Imelda Bates y Mike A. Laffan, ha sido la referencia en todo el mundo en hematología de laboratorio. Internacionalmente reconocida como la obra de referencia para los laboratorios de hematología, este manual práctico describe todas las técnicas utilizadas en la investigación de los pacientes con enfermedades sanguíneas. Analiza los principios de cada prueba, las causas posibles de error, el razonamiento para elegir un método u otro y la interpretación, significado e importancia clínica de los resultados. Aborda las últimas tecnologías y procedimientos en el trabajo de laboratorio. Incluye nueva información sobre seguridad en el laboratorio, proporcionando una guía sobre los riesgos de cada procedimiento. Hace hincapié en los detalles técnicos de los métodos, junto con una perspectiva crítica sobre su interpretación y utilidad clínica. Ofrece directrices útiles a todos los niveles, desde los centros primarios de salud, donde solo se realizan unas pocas pruebas diagnósticas, hasta centros especializados con tecnología sofisticada. Proporciona árboles de decisión que ayudan a enfrentarse a diversas situaciones clínicas desde el punto de vista de los análisis de laboratorio. Incluye capítulos sobre organización, dirección y control de calidad del laboratorio. Dispone de contenido adicional en ExpertConsult que permite búsquedas en todo el texto y referencias en una gran variedad de dispositivos.

Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part A, Volume 365 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release include MPN a continuum of different disease entities, Bone marrow microenvironment of MPN, Extramedullary hemopoiesis in MPN, The JAK2 mutation, Calreticulin mutations in myeloproliferative neoplasms, and Cytogenetic abnormalities and non-driver mutations in MPN. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists and drawn from international sources Offers a wide range of perspectives on specific subjects

Flow Cytometry of Hematological Malignancies Flow cytometric analysis is often integral to the swift and accurate diagnosis of leukemias and lymphomas of the blood, bone marrow, and lymph nodes. However, in the fast-moving and expanding field of clinical hematology, in can be challenging to remain up to speed with the latest biological research and technological innovations. Flow Cytometry of Hematological Malignancies has been designed to provide all those working in hematological oncology with a practical, cutting-edge handbook, featuring clear and fully illustrated guidance on all aspects of cytometry’s role in diagnosis and analysis. This essential second edition includes: Explorations of more than 70 antigens Full-color illustrations throughout New descriptions of recently discovered markers WHO classifications of hematological neoplastic diseases Helpful tips for result interpretation and analysis Featuring all this and more, Flow Cytometry of Hematological Malignancies, Second Edition, is an invaluable resource for both trainee and experienced hematologists, hematopathologists, oncologists, and pathologists, as well as medical students and diagnostic lab technicians.