The Promise Of Lithium

For most patients, a diagnosis of Alzheimer's or Parkinson's places a looming specter over the future without any proven treatment to stop the inevitable progression of symptoms. Based on a serendipitous discovery in a patient with Parkinson's, The Promise of Lithium describes, in easy-to-understand language, the compelling body of evidence dating as far back as 1959 supporting the use of over-the-counter (OTC) lithium supplementation to potentially slow the progression of both Alzheimer's and Parkinson's. Discover the pros and cons of the two OTC lithium formulations available and the important background information you will need to decide if OTC lithium is right for you and at what dosage. If you or a loved one is living with a diagnosis of Alzheimer's or Parkinson's, time is of the essence to quell their destructive processes. The Promise of Lithium provides great hope that simple OTC lithium supplementation may preserve these patients' futures.

The remarkable untold story of a miracle drug, the forgotten pioneer who discovered it, and the fight to bring lithium to the masses. The DNA double helix, penicillin, the X-ray, insulin—these are routinely cited as some of the most important medical discoveries of the twentieth century. And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most important—yet largely unsung—breakthroughs of the modern era. In Lithium, Walter Brown, a practicing psychiatrist and professor at Brown, reveals two unlikely success stories: that of John Cade, the physician whose discovery would come to save an untold number of lives and launch a pharmacological revolution, and that of a miraculous metal rescued from decades of stigmatization. From insulin comas and lobotomy to incarceration to exile, Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade’s “Lithium Salts in the Treatment of Psychotic Excitement” described, for the first time, lithium’s astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented. With a vivid portrait of the story’s unlikely hero, John Cade, Brown also describes a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources (Cade’s “laboratory” was the unused pantry of an isolated mental hospital). As Brown shows, however, these humble conditions were the secret to his historic success: Cade was free to follow his own restless curiosity, rather than answer to an external funding source. As Lithium makes tragically clear, medical research—at least in America—has transformed in such a way that serendipitous discoveries like Cade’s are unlikely to occur ever again. Recently described by the New York Times as the “Cinderella” of psychiatric drugs, lithium has saved countless of lives and billions of dollars in healthcare costs. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical history—revealing just how close we came to passing over this extraordinary cure.

In a nation plagued with chronic diseases such as cancer, heart disease, and diabetes, a different predator is the single greatest reason for disability in the United States: mental disorders. Our fast-paced and frenetic lifestyle, coupled with a grossly polluted environment, has created the perfect breeding ground for mental instability. With the spread of brain disorders on the rise around the world, nutritional biochemistry and one of its stars, lithium, has stepped into the spotlight to offer proven methods to heal our bodies from the inside out. Historically linked to severe psychiatric illness, lithium as an agent of good health and well-being is often ignored and brushed aside. Known as the Cinderella drug, it is an essential mineral in our physical and psychological makeup. Lack of its presence in the body can result in poor brain development, psychiatric symptoms, and so on. When administered in small, controlled doses, lithium can significantly improve the lives of those suffering from mental disorders. Nutritional Lithium: A Cinderella Story illustrates the significance of this precious mineral not only as a nutrient vital to human development, but also as a nutritional component that can help millions of people worldwide.

This book presents recent advances in dynamics and control of different types of energy systems. It covers research on dynamics and control in energy systems from different aspects, namely, combustion, multiphase flow, nuclear, chemical and thermal. The chapters start from the basic concepts so that this book can be useful even for researchers with very little background in the area. A dedicated chapter provides an overview on the fundamental aspects of the dynamical systems approach. The book will be of use to researchers and professionals alike.

Heavy-Duty Electric Vehicles: From Concept to Reality presents a step-by-step design and development guide for heavy-duty electric vehicles. It also offers practical insights based on the commercial application of an electric city bus. Heavy-duty electric vehicle design is challenging due to a lack of clear understanding of the government policies, R&D directions and uncertainty around the performance of various subsystems in an electric powertrain. Therefore, this book discusses key technical aspects of motors, power electronics, batteries and vehicle control systems, and outlines the system integration strategies necessary for design and safe operation of electric vehicles in practice. This comprehensive book serves as a guide to engineers and decision makers involved in electric vehicle development programs and assists them in finding the suitable electric powertrain solution for a given heavy-duty vehicle application. Offers an overview of various standards and regulations that guide the electric vehicle design process and a comprehensive discussion on various government policies and incentive schemes propelling the growth of heavy electric vehicle markets across the world Provides a comparative evaluation of different electric drivetrain concepts and a step-by-step power calculation guide for heavy-duty electric powertrain Explains material selection and manufacturing methods for next generation batteries Discusses key elements and design rules for creating a robust high voltage energy storage system, appropriate packaging and its support systems including charging network Includes a concise description of torque mapping, power management and fault handling strategies for inverter drive and control systems Features case studies to better understand complex topics like charging system requirements and vehicle control system diagnostics

This book discusses systematically the theoretical research and the applications of electrochemical oxygen reduction. Oxygen reduction reaction is a common issue in electrochemistry, but is also an important process involved in the field of energy, cryogenic fuel cells, metal–air cells, oxygen sensors and hydrogen peroxide preparation. This book is divided into 6 chapters; it starts with a description of dynamic mechanisms, followed by a detailed introduction on the related experimental methods and related catalyst preparation technology. By providing the basic methods and testing techniques, and by demonstrating their applications, it helps readers gain a better understanding of oxygen reduction reactions, making it a valuable resource for the industrialization of scientific research achievements. Accordingly, the book appeals to a broad readership, particularly graduate students, those working at universities and research organizations, and industrial researchers.

A practical guide that helps pastoral ministers to recognize and deal with the array of common mental health problems in their ministry, including depression, anxiety, addictions and personality disorders.