Ntp Technical Report On The Toxicology And Carcinogenesis Studies Of Acetonitrile Cas No 75 05 8 In F344 N Rats And B6c3f1 Mice Inhalation Studies

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Methylene Blue Trihydrate (MBT) has a variety of biomedical and biologically therapeutic applications. MBT was nominated by the Nat. Cancer Inst. for carcinogenecity testing based on the numerous uses of this compound and the lack of long-term toxicity data, including epidemiological studies of MBT, as well as the inadequate animal data on this compound. Male and female F344/N rats and B6C3F1 mice were administered MBT in 0.5% aqueous methylcellulose by gavage for 1 month, 3 months, or 2 years. Genetic toxicology studies were conducted using ¿Salmonella typhimurium,¿ ¿Escherichia coli,¿ cultured Chinese hamster ovary cells, mouse bone marrow cells, and mouse peripheral blood erythrocytes. Illustrations.

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