Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic And Germ Cell Gene Mutation Assays
Download Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic And Germ Cell Gene Mutation Assays full books in PDF, epub, and Kindle. Read online free Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic And Germ Cell Gene Mutation Assays ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Test No 488 Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 16 |
Release | : 2011-07-28 |
Genre | : Electronic Book |
ISBN | : 9789264122819 |
Download Test No 488 Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays Book in PDF, Epub and Kindle
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...
OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 37 |
Release | : 2022-06-30 |
Genre | : Electronic Book |
ISBN | : 9789264366060 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay Book in PDF, Epub and Kindle
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
OECD Guidelines for the Testing of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 28 |
Release | : 2022-06-30 |
Genre | : Electronic Book |
ISBN | : 9789264203907 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays Book in PDF, Epub and Kindle
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations in somatic and germ cells. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The transgenes contain reporter genes for the detection of various types of mutations induced by test chemicals.
OECD Guidelines for the Testing of Chemicals Section 4 Test No 485 Genetic toxicology Mouse Heritable Translocation Assay
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 6 |
Release | : 1986-10-23 |
Genre | : Electronic Book |
ISBN | : 9789264071506 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 485 Genetic toxicology Mouse Heritable Translocation Assay Book in PDF, Epub and Kindle
The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...
OECD Guidelines for the Testing of Chemicals Section 4 Test No 476 In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 18 |
Release | : 2016-07-29 |
Genre | : Electronic Book |
ISBN | : 9789264264809 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 476 In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes Book in PDF, Epub and Kindle
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...
OECD Guidelines for the Testing of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 24 |
Release | : 2016-07-29 |
Genre | : Electronic Book |
ISBN | : 9789264264908 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene Book in PDF, Epub and Kindle
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
OECD Guidelines for the Testing of Chemicals Section 4 Test No 478 Rodent Dominant Lethal Test
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 15 |
Release | : 2016-07-29 |
Genre | : Electronic Book |
ISBN | : 9789264264823 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 478 Rodent Dominant Lethal Test Book in PDF, Epub and Kindle
The purpose of the Dominant lethal (DL) test is to investigate whether chemical agents produce mutations resulting from chromosomal aberrations in germ cells.
OECD Guidelines for the Testing of Chemicals Section 4 Test No 484 Genetic Toxicology Mouse Spot Test
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 4 |
Release | : 1986-10-23 |
Genre | : Electronic Book |
ISBN | : 9789264071483 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 484 Genetic Toxicology Mouse Spot Test Book in PDF, Epub and Kindle
The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...