Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig A Gene Mutation Assay
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OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 37 |
Release | : 2022-06-30 |
Genre | : Electronic Book |
ISBN | : 9789264366060 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay Book in PDF, Epub and Kindle
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
OECD Guidelines for the Testing of Chemicals Section 4 Test No 476 In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 18 |
Release | : 2016-07-29 |
Genre | : Electronic Book |
ISBN | : 9789264264809 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 476 In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes Book in PDF, Epub and Kindle
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...
OECD Guidelines for the Testing of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 24 |
Release | : 2016-07-29 |
Genre | : Electronic Book |
ISBN | : 9789264264908 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene Book in PDF, Epub and Kindle
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Test No 474 Mammalian Erythrocyte Micronucleus Test
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 21 |
Release | : 2014-09-26 |
Genre | : Electronic Book |
ISBN | : 9789264224292 |
Download Test No 474 Mammalian Erythrocyte Micronucleus Test Book in PDF, Epub and Kindle
The mammalian in vivo micronucleus test detects damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals.
OECD Guidelines for the Testing of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 28 |
Release | : 2022-06-30 |
Genre | : Electronic Book |
ISBN | : 9789264203907 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays Book in PDF, Epub and Kindle
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations in somatic and germ cells. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The transgenes contain reporter genes for the detection of various types of mutations induced by test chemicals.
OECD Guidelines for the Testing of Chemicals Section 4 Test No 485 Genetic toxicology Mouse Heritable Translocation Assay
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 6 |
Release | : 1986-10-23 |
Genre | : Electronic Book |
ISBN | : 9789264071506 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 485 Genetic toxicology Mouse Heritable Translocation Assay Book in PDF, Epub and Kindle
The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...
OECD Guidelines for the Testing of Chemicals Section 4 Test No 479 Genetic Toxicology In vitro Sister Chromatid Exchange Assay in Mammalian Cells
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 5 |
Release | : 1986-10-23 |
Genre | : Electronic Book |
ISBN | : 9789264071384 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 479 Genetic Toxicology In vitro Sister Chromatid Exchange Assay in Mammalian Cells Book in PDF, Epub and Kindle
The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...
OECD Guidelines for the Testing of Chemicals Section 4 Test No 471 Bacterial Reverse Mutation Test
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 11 |
Release | : 2020-06-29 |
Genre | : Electronic Book |
ISBN | : 9789264071247 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 471 Bacterial Reverse Mutation Test Book in PDF, Epub and Kindle
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...