Orthobiologics

The foundation of fracture fixation resides with metal implants that provide stability, restore length, obtain alignment, maintain a reduction, and provide the body the opportunity to repair itself. In recent years, the focus has shifted from simply "repairing" fractures to "healing" them. Orthobiologics: Improving Fracture Care Through Science reviews the growing role of orthobiologics in fracture care and offers orthopaedic surgeons strategies for choosing "graft" material when confronted with difficult fractures. The text provides case studies, algorithms, and an overview of this complex, dynamic field.

Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by internationally renowned experts Drs. Scott P. Bruder and Roy K. Aaron, Orthobiologics: Scientific and Clinical Solutions for Orthopaedic Surgeons provides authoritative, comprehensive coverage of this fast-growing field. This one-stop reference is an ideal resource, covering technology and basic science through specific clinical applications.

This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.

This issue of Orthopedic Clinics focuses on Orthobiologics. Article topics include: Does Prior Cartilage Restoration Impact Outcomes Following Knee Arthroplasty?; Clinical Applications of Tissue Engineering in Joint Arthroplasty: Current Concepts Update; Usage of Bone Graft Substitutes; Bone morphogenetic protein; Role of Bone Marrow Aspirate in Orthopaedic Trauma; Orthobiologics in Pediatric Sports Medicine, and more!

In this issue of Physical Medicine and Rehabilitation Clinics, guest editors Drs. Michael Khadavi and Luga Podesta bring their considerable expertise to the topic of Orthobiologics. Use and research surrounding naturally derived substances that are used to help heal and repair orthopedic injuries are expanding rapidly. In this issue, top experts discuss the most up-to-date uses of orthobiologics in the rehabilitation setting. Contains 16 practice-oriented topics including orthobiologics for spine disorders; evidence and techniques in prolotherapy; orthobiologic interventions for muscle injuries; special populations in orthobiologics: athletic, elderly, and pediatrics populations; rehabilitation protocols for orthobiologic procedures; orthobiologic techniques for surgical augmentation; and more. Provides in-depth clinical reviews on orthobiologics, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Guest edited by Drs. Rachel Frank and Brian Cole, this issue of Clinics in Sports Medicine will cover several key areas of interest related to OrthoBiologics in Sports Medicine. This issue is one of four selected each year by the series Consulting Editor, Dr. Mark Miller. Articles in this issue include: Corticosteroids and Hyaluronic Acid Injections, Platelet Rich Plasma, Adipose Derived Stem Cell Treatments and Formulations, Amniotic Derived Treatments and Formulations, Orthobiologics For Ligament Repair and Reconstruction, Orthobiologics For Bone Healing, Orthobiologics For Focal Articular Cartilage Defects, OrthoBiologics for Osteoarthritis, Emerging Orthobiologics Techniques and The Future, and Incorporating Orthobiologics Into Your Clinical Practice.

This book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body’s natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, including biomaterials, growth factors, and autogenous cells, together provide the basis for the regeneration of these musculoskeletal structures and how recent scientific progress has created unique opportunities to address pathological situations that until recently have been treated with unsatisfactory results. The authors are experts from across the world who come together to provide a truly global overview. The book is published in collaboration with ISAKOS. It will be invaluable for all with an interest in this area of medicine, which has already attained huge popularity in Orthopaedics and Sports Medicine and has also attracted the attention of the lay public.

This book provides a comprehensive, state-of-the art summary of platelet rich plasmas (PRPs) in the field of regenerative medicine. The book begins with an overview of the basic science behind PRP, describing the role of platelets and growth factors followed by the most important biological effects expected from the use of PRPs. Platelet Rich Plasma in Orthopaedics, Sports Medicine and Maxillofacial Surgery includes numerous contributions detailing the current use of PRPs in clinical practice. From the origins in oral and maxillofacial surgery, to the latest advances in orthopaedics and sports medicine including the use of Platelet Rich Growth Factors (PRGF) in muscle, bone, tendon, ligament and nerve injuries, this book provides a wide scope of the topic. The volume concludes with chapters from experts in biology, orthopaedics, oral and maxillofacial surgery, where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of PRGF. This book will provide a useful resource for physicians and researchers interested in learning more about this rapidly growing area of biomedical treatment.