Paul Ehrlich S Receptor Immunology

Paul Ehrlich's Receptor Immunology: The Magnificent Obsession describes the background to Paul Ehrlich's immunological works and theories and delves into the substance of his experiments in great detail. By exploring these early developments in immunology, the book lays the foundation for modern concepts, providing immunologists, biomedical researchers, and students the context for the discoveries in their field. The selectionist theory of antibody formation Kinetics of primary and secondary antibody response Quantitative methods of measurement of antigens and antibody Demonstration of passive transfer of immunity from mother to foetus

A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

A cutting-edge collection of readily reproducible techniques for the isolation, culture, and study of activation and signaling in human mast cells. These methods take advantage of the latest advances in molecular biology, technology, and information science. They include methods for the identification of mast cells, the development of mast cells in vitro, the study of mast cell signaling and gene expression, and the measurement of mast cell expression of inflammatory mediators. Additional chapters cover methods for studying mast cell interactions with other cell types (endothelial cells, fibroblasts, and B cells), the roles of mast cells in host defense, and mast cell apoptosis.

The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. Current and thorough 30 chapter reference reviewed by luminaries in the field Unique ‘single voice' ensures consistency of definitions and concepts Comprehensive and elegant illustrations bring key concepts to life Provides historical context to allow fuller understanding of key issues Introductory chapters 1-4 serve as an ‘Immunology Primer' before topics are discussed in more detail

The Collected Papers of Paul Ehrlich, Volume I covers topics on histology, biochemistry, and pathology. The book presents topics on practice and theory of staining in histology; cytology of the blood in health and disease; and the staining of bacteria and its application to diagnosis. The text also includes topics on the requirement of the organism for oxygen and other allied biochemical studies; pharmacology, therapeutics and toxicology; and the diazobenzenesulphonic acid and dimethylaminobenzaldehyde reactions.

Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs. Estimates of 200 000 natural products in plant species have been revised upward as mass spectrometry techniques have developed. For developing countries the identification and use of endogenous medicinal plants as cures against cancers has become attractive. Books on drug discovery will play vital role in the new era of disease treatment using natural products.

Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomen