A Historical Perspective On Evidence Based Immunology

A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

Systems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology. The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.

The COVID-19 pandemic provides stark evidence of the importance of medicine on a global scale. However, revisiting the influenza pandemic of 1918 provided a perspective as we searched for a viable vaccine and instituted public health measures. This shows that medical knowledge is an accumulative process extending to the past and it is in the spirit of that legacy that this bibliography has been compiled. The book is a one-stop resource that cites literature related to the historical aspects of medicine. It also acknowledges medicine’s global reach and devotes significant effort in that respect. Although the online world seems to dominate on both a social and educational level, there is still a need for thoughtfully curated and focused reference works and this bibliography accomplishes that goal. The book has 9,000+ citations. It utilizes the WHO's International classification of Diseases for the section on diseases and disorders and the U.S. Food & Drug Administration's Product Code Classification Database for the section on medical devices, equipment, and instruments. It includes detailed subject, geographuc, and people indexes for an easy reference.

“Fascinating.…[Ravella’s writing] breathes life into biological functions.” —Grace Wade, New Scientist A riveting investigation of inflammation—the hidden force at the heart of modern disease—and how we can prevent, treat, or even reverse it. Inflammation is the body’s ancestral response to its greatest threats, the first line of defense it deploys against injury and foreign pathogens. But as the threats we face have evolved, new science is uncovering how inflammation may also turn against us, simmering underneath the surface of leading killers from heart disease and cancer to depression, aging, and mysterious autoimmune conditions. In A Silent Fire, gastroenterologist Shilpa Ravella investigates hidden inflammation’s emerging role as a common root of modern disease—and how we can control it. We meet the visionary nineteenth-century pathologist who laid the foundation for our modern understanding of inflammation, the eccentric Russian zoologist who discovered one of the cells central to our immune system, and the dedicated researchers advancing the frontiers of medical and nutritional science today. With fascinating case studies, Ravella reveals how we can reform our relationships with food and our microbiomes to benefit our own health and the planet’s. Synthesizing medical history, cutting-edge research, and innovative clinical practice, Ravella unveils inflammation as one potential basis for a unifying theory of disease. A paradigm-shifting understanding of one of the most mysterious, buzzed-about topics in medicine and nutrition, A Silent Fire shows us how to live not only long but well.

Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Our immune system defends us against infection by employing multiple lines of defense. The relevance of the immune response in human health, disease prevention, and vaccinations becomes evident when the immune system is compromised as in the case of pathogenic infections or autoimmune diseases. The reader will gain a fundamental understanding of the essential principles of immunology, such as how our immune system recognizes/fights infectious agents, how our body differentiates between foreign and self-cells/molecules, and how the memory from previous infections aids in a faster and more effective immune response. The book is divided into 17 chapters, providing an overview of the immune system and its components, including its organs and cells. Chapters on the major histocompatibility complex, the complement system, hypersensitivity and tolerance, antibody diversity through DNA rearrangements, and autoimmune diseases are included in the book which further broadens the understanding of this very complex system of our body. Chapters on transplantation immunology and vaccines provide a perspective on the application of these immunological concepts and will be of great interest to readers. Key features of the book: Simple, direct, and lucid language Comprehensive coverage of concepts for better understanding Well-labeled illustrations, flowcharts, and tables for enhanced learning Every chapter is followed up with a detailed summary and questionnaire A detailed glossary for users to know the right words Chapters contributed/reviewed by experienced experts in this field The book provides broad, accessible, and up-to-date information about immunological perspectives to biotechnologists, biomedical scientists, biochemists, molecular biologists, and students from various streams of life sciences, including zoology, biotechnology, and microbiology, as well as instant access to a wealth of information.

The Theory of Endobiogeny Volume 2: Foundational Concepts for Treatments of Common Clinical Conditions addresses the core elements of the adaptation response to stressors: autonomic nervous system (ANS), corticotropic axis, immunity and digestive tract function. The volume is oriented for clinical practice, offering clear discussions on treating the root cause of numerous common disorders, and symptomatically addressing the destabilizing factor in a vast number of disorders ranging from depression to irritable bowel, and from migraines to insomnia called spasmophilia. Extends the concepts of global systems integrative physiology to practical applications in the clinic Detailed explanations of historical, exam and biological modeling indexes related to the ANS, corticotropic axis, hepatobiliary and exocrine pancreatic function Root cause, mechanisms, symptoms and treatments for disorders of immunity, dysbiosis, infectious diseases and spasmophilia, as well as hepatobiliary and pancreatic insufficiency and congestion Materia medica of 22 key medicinal plants with summary of action and indication of usage according to the theory of Endobigoeny Special monodiets and dietary suggestions for disorder discussed