Pharmacology Of Reproduction

Pharmacology of Reproduction is the second volume of the proceedings of the Third International Pharmacological Meeting held in Sao Paulo in 1966. The volume presents papers about the pharmacological implications of the hypothalamic control of gonadotrophin and prolactin secretion and the factors affecting hypothalamic function, with focus on the pharmacology of puberty. The luteinizing hormone (LH)-like activity in the pituitary-hypothalamic complex of children and the chemistry and physiology of follicle-stimulating hormone-releasing factor and LH-release factor are studied as well in other papers presented. The volume then tackles papers about the factors affecting the testicular function in human; immunological factors affecting spermatogenesis; and the factors stimulating the ovarian function in human. The pharmacological inhibition of the ovarian function is also considered in the volume. Practicing endocrinologists and physiologists and students taking endocrinology courses will find the book invaluable.

This unique source of reference provides a comprehensive guide to the adverse side-effects of many commonly prescribed drugs on fertility and sexual health. More than 150 drugs are listed in this compilation, and the evidence linking them with infertility and sexual dysfunction is carefully reviewed. The volume is designed to provide a rapid source of reference to alert doctors and pharmacists to these hazardous side-effects. The volume also includes an introductory account of the reproductive process and a review of the mechanisms by which these drugs can interfere or inhibit reproduction. Another important theme of the volume is the effect of social and recreational drugs and environmental agents on reproductive health.

This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working in this vital field of study./div

A 1981 treatment of the action and uses of the hormones and drugs that influence endocrine functions in the body as seen by a pharmacologist. The book includes a description of available drug preparations and expected therapeutic responses, and an examination of their side effects and interactions with other drugs. Special emphasis is placed on how such drugs and hormones work and on how their biological effects are related to their chemical structures. The physiological background to the practical significance of such substances is given for both a healthy and a diseased state. The book assumes little prior knowledge of endocrinology or pharmacology.