Podocytopathy

The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.

Chronic kidney disease is a worldwide disease affecting up to 4% of the population. In many cases, glomerulonephritis is the underlying disease leading to kidney failure. One hallmark of glomerulonephritis is proteinuria, which may in its most severe form lead to nephrotic syndrome. In seven chapters, this book puts light on different aspects related to the pathophysiology and clinical aspects of glomerulonephritis. In addition, chapters dealing with the importance of biomarkers in patients with glomerulonephritis will be beneficial for the open-minded reader. Nevertheless, new insights in renal rehabilitation in patients with chronic kidney disease will be provided.

This issue of Rheumatic Disease Clinics, guest edited by Drs. Andrew Bomback and Meghan Sise, will cover several key aspects of Renal Involvement in Rheumatic Diseases. The Consulting Editor for the series is Dr. Michael Weisman. The topics discussed in the issue will include: ANCA, Lupus GN, proliferative and non-proliferative, Renal manifestations of RA, Secondary amyloidosis, Nephrotoxicity of select rheumatology drugs, Acute and chronic TI nephritis, rheumatology etiologies, TMAs with rheum etiologies, Anti-GBM, Autoimmune manifestations of viral infections, and Renal manifestations of IBD, among others.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of common and rare nonneoplastic renal diseases, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, Diagnostic Pathology: Kidney Diseases, fourth edition, is a visually stunning, one-stop resource for every practicing pathologist, nephrologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. Provides a comprehensive source for key pathologies and clinical features of more than 265 kidney diseases Features two dozen new chapters on a variety of timely topics, including COVID-19 nephropathies, xenografts, artificial intelligence (AI), digital pathology analysis, harmonized nephropathology terminology, newly identified types of amyloidosis, common artifacts and pitfalls on kidney biopsy, vaccination-associated renal disease, crystal nephropathies, and much more Includes updates from the International Kidney and Monoclonal Gammopathy (IKMG) research group, the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for IgG4-related disease, Banff Foundation for Allograft Pathology, and others Details updated genetic causes of nephrotic syndromes and antinephrin antibodies in podocytopathies—by the investigator who discovered it Discusses the newly identified variant IgG nephropathy and novel membranous autoantigens Contains chapters on techniques, including immunofluorescence on paraffin sections, C4d staining, and polyomavirus detection in tissue Contains more than 4,300 print and online images, including high-resolution photographs and histologic images, full-color medical illustrations, radiologic images, and more Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care Shares the expertise of internationally recognized authors who provide fresh perspectives on multiple topics, with a particular emphasis on practical information that directly assists in making and supporting a diagnosis

The third edition of a bestseller, this book provides insight from a wide array of international contributors in the field of pediatric nephrology. Copiously illustrated with photomicrographs and clinical diagrams, the third edition reflects current advances in the field. Each chapter contains a set of questions, directed at helping fellows succeed at the American Pediatric Nephrology Board examination. New information for this edition includes changes in treatment options for hyponatremia, and updates on hyperparathyroidism and transplantation. Text boxes highlight important "take home points" throughout the chapters. Clinical Pediatric Nephrology, Third Edition will be a valuable reference for clinicians in nephrology, pediatrics and urology, and any professional involved in the care of children with renal diseases seeking a reliable contemporary text.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of nonneoplastic pediatric pathology, it incorporates the most recent clinical, pathological, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, Diagnostic Pathology: Nonneoplastic Pediatrics, second edition, is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides a clear framework for a better understanding of the clinical and histopathologic appearances of more than 270 nonneoplastic entities, covering every organ system with a focus on reactive, infectious, congenital, and genetic conditions Covers significant advances in this complex field, including recent molecular discoveries and updated disease entities, new information on multiple immunologic disorders, changes and expansions to several classification systems (such as WHO, Banff, and ISSVA), and updates in other scoring systems Contains new chapters on manifestations of pediatric COVID-19 infection, tumoral calcinosis, multiple skeletal dysplasia, skeletal muscle, collagenous gastritis and colitis, adenovirus appendicitis, intestinal pseudoobstruction, disorders of sexual development, and Kikuchi disease Includes approximately 3,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis—as well as nearly 200 additional images online Employs consistently templated chapters and bulleted content for quick, expert reference at the point of care

For nearly 60 years, Heptinstall’s Pathology of the Kidney has been the reference of choice for both pathologists and nephrologists for expert, authoritative coverage of kidney disease. The fully revised and reorganized Eighth Edition, edited by Drs. J. Charles Jennette, Vivette D. D’Agati, Agnes B. Fogo, Volker Nickeleit and Michael Barry Stokes offers thorough pathologic descriptions, important clinical correlations, and up-to-date discussions of causes and pathogenesis to improve understanding of kidney disease and to facilitate accurate diagnosis and optimum care of patients with kidney disease. Now in a single volume, this image-rich text conveys the unique challenges and intricacies of renal disease, offering powerful diagnostic and treatment recommendations from decades of clinical research.