Preventing Biological Warfare

What is bioterrorism and how can the United States prepare and defend itself from this threat? Readers will learn about the history of biological warfare and terrorism—from ancient to medieval to modern times. Stories of a salmonella cult attack, a smallpox outbreak war game to test the nation’s readiness for a biological attack, and biosecurity breaches in Tokyo describe some of the nation’s experiences with biological warfare. Through informative text, full-color photos, and fact boxes, this book details US Army training against bioweapons, the future of biosecurity, and the prevention of bioweapon proliferation in the global community.

Web of Prevention provides a timely contribution to the current debate about life science research and its implications for security. It is an informative guide for both experts and the public. It is a forward-looking contribution covering both ends of the equation and creates momentum for the current discussion on effective preventive measures and effective control measures. While there are no guarantees for preventing misuse, there are nonetheless crucial steps the world community can take towards the overarching goal of a global network for the life sciences. This book sheds light on concrete steps toward the achievement of this worthy goal. "This book with its collection of essays provides an in-depth analysis of the various mutually reinforcing elements that together create and strengthen a web of prevention - or of assurance - that is vital to ensure that the advances in the life sciences are not misused to cause harm. All those engaged in the life sciences and in policy making in governments around the world should read this book so they can take steps to strengthen the web preventing biological weapons". From the Foreword by Dr Gabriele Kraatz-Wadsack, Chief, Weapons of Mass Destruction Branch, Office for Disarmament Affairs, United Nations. "Since September 11, 2001 in many countries renewed attention has been given to how research in the life sciences might inadvertently or intentionally facilitate the development of biological or chemical weapons. This state-of-the-art volume examines the full extent of the issues and debates. Coverage includes an overview of recent scientific achievements in virology, microbiology, immunology and genetic engineering with a view to asking how they might facilitate the production of weapons of mass destruction by state, sub-state or terrorist organizations. Consideration is given to what we have and haven't learned from the past. Employing both academic analysis and reflections by practitioners, the book examines the security-inspired governance regimes for the life sciences that are under development. Ultimately the authors examine what is required to form a comprehensive and workable web of prevention and highlight the importance of encouraging discussions between scientists, policy makers and others regarding the governance of vital but potentially dangerous research". Dr Graham S. Pearson, Visiting Professor of International Security, University of Bradford, UK and previously Director-General, Chemical and Biological Defence Establishment, UK

This timely sourcebook presents the essential technical, political, legal, and historical background needed for informed judgments about the recent expansion of military interest in the life sciences particularly in the weapons potential of the new biotechnology. Beyond providing a history and analysis of trends in these areas, "Preventing a Biological Arms Race also develops the case for strengthening national and international commitments to biological disarmament and proposes courses of action to achieve this goal. "In theory, " Susan Wright observes, "the menace of biological warfare should no longer be with us." Developing, producing, and stockpiling biological weapons are unconditionally banned by international treaty. EastWest military rivalry and confrontations in the Middle East have eroded confidence in the treaty regime, however. The advent of genetic engineering and other new biotechnologies has revived military interest in biological weaponry, generating concern about the potential weapons applications of biological research. The 15 contributions by experts from a wide range of disciplines include a history of U.S. biological warfare policy, analysis of the ethical issues posed by defensive biological warfare research, case studies of alleged violations of the international legal regime prohibiting biological weapons, reviews of that regime, and proposals for strengthening the barriers to biological warfare. A series of 14 appendices collect important data and documents related to biological weapons. Susan Wright is a historian of science at the Residential College of the University of Michigan where she directs the Science and Society Program. This book was prepared underthe sponsorship of the Council for Responsible Genetics.

The attacks of September 11 and the release of anthrax spores revealed enormous vulnerabilities in the U.S. public-health infrastructure and suggested similar vulnerabilities in the agricultural infrastructure as well. The traditional public health response-surveillance (intelligence), prevention, detection, response, recovery, and attribution-is the paradigm for the national response not only to all forms of terrorism but also to emerging infectious diseases. Thus, investments in research on bioterrorism will have enormous potential for application in the detection, prevention, and treatment of emerging infectious diseases that also are unpredictable and against which we must be prepared. The deciphering of the human genome sequence and the complete elucidation of numerous pathogen genomes, our rapidly increasing understanding of the molecular mechanisms of pathogenesis and of immune responses, and new strategies for designing drugs and vaccines all offer unprecedented opportunities to use science to counter bioterrorist threats. But these same developments also allow science to be misused to create new agents of mass destruction. Hence the effort to confront bioterrorism must be a global one. Countering Bioterrorism makes the following recommendations: Recommendation 1: All agencies with responsibility for homeland security should work together to establish stronger and more meaningful working ties between the intelligence, S&T, and public health communities. Recommendation 2: Federal agencies should work cooperatively and in collaboration with industry to develop and evaluate rapid, sensitive, and specific early-detection technologies. Recommendation 3: Create a global network for detection and surveillance, making use of computerized methods for real-time reporting and analysis to rapidly detect new patterns of disease locally, nationally, and ultimately- internationally. The use of high-throughput methodologies that are being increasingly utilized in modern biological research should be an important component of this expanded and highly automated surveillance strategy. Recommendation 4: Use knowledge of complex biological patterns and high-throughput laboratory automation to classify and diagnose infections in patients in primary care settings. Recommendation 5: USDA should create an agency for control and prevention of plant disease. This agency should have the capabilities necessary to deal effectively with biothreats.

The Biological and Toxin Weapons Convention entirely prohibits biological warfare, but it has no effective verification mechanism to ensure that the 140-plus States Parties are living up to their obligations. From 1995-2001 the States Parties attempted to negotiate a Protocol to the Convention to remedy this deficiency. On 25 July 2001 the United States entirely rejected the final text which would probably have been acceptable to most other states. The book investigates how this disaster came about, and the potential consequences of the failure of American leadership.

Preventing a Biochemical Arms Race responds to a growing concern that changes in the life sciences and the nature of warfare could lead to a resurgent interest in chemical and biological weapons (CBW) capabilities. By bringing together a wide range of historical material and current literature in the field of CBW arms control, the book reveals how these two disparate fields might be integrated to precipitate a biochemical arms race among major powers, rogue states, or even non-state actors. It seeks to raise awareness among policy practitioners, the academic community, and the media that such an arms race may be looming if developments are left unattended, and to provide policy options on how it—and it's devastating consequences—could be avoided. After identifying weaknesses in the international regime structures revolving around the Biological Weapons and Chemical Weapons Conventions, it provides policy proposals to deal with gaps and shortcomings in each prohibition regime individually, and then addresses the widening gap between them.

Biosecurity and Bioterrorism, Second Edition, takes a holistic approach to biosecurity, with coverage of pathogens, prevention, and response methodology. It addresses these hazards in the context of vulnerability assessments and the planning strategies government and industry can use to prepare for and respond to such events. The book is organized into four thematic sections: Part I provides a conceptual understanding of biowarfare, bioterrorism and the laws we have to counteract this; Part II investigates known bioagents and the threat from emerging diseases; Part III focuses on agricultural terrorism and food security; and Part IV outlines international, US, and local initiatives for biodefense and biosecurity. Case studies illustrate biodefense against both intentional terrorism and natural outbreaks. Covers emerging threats of pandemic influenza, antibiotic resistant strains of bacterial pathogens, and severe respiratory diseases caused by novel viruses Offers increased international coverage, including initiatives to counter biological weapons and threats, and food security Updated throughout with latest protocols for dealing with biological threats and new case studies Includes online instructor ancillaries - PowerPoint lecture slides, test questions, and an instructor manual, for increased classroom functionality

Handbook on Biological Warfare Preparedness provides detailed information on biological warfare agents and their mode of transmission and spread. In addition, it explains methods of detection and medical countermeasures, including vaccine and post-exposure therapeutics, with specific sections detailing diseases, their transmission, clinical signs and symptoms, diagnosis, treatment, vaccines, prevention and management. This book is useful reading for researchers and advanced students in toxicology, but it will also prove helpful for medical students, civil administration, medical doctors, first responders and security forces. As the highly unpredictable nature of any event involving biological warfare agents has given rise to the need for the rapid development of accurate detection systems, this book is a timely resource on the topic. Introduces different bacterial and viral agents, including Ebola and other emerging threats and toxins Discusses medical countermeasures, including vaccines and post-exposure therapeutics Includes a comprehensive review of current methods of detection