Principles Of Physical Biochemistry

Table of Contents Preface. I. MACROMOLECULAR STRUCTURE AND DYNAMICS. 1. Biological Macromolecules. 2. Thermodynamic Principles. 3. Molecular Thermodynamics. 4. Statistical Mechanics. 5. Methods for the Separation and Characterization of Macromolecules. 6. X-Ray Diffraction. 7. Scattering from Solutions of Macromolecules. II. SPECTROSCOPY 8. Quantum Mechanics and Spectroscopy. 9. Absorption Spectroscopy. 10. Linear and Circular Dichroism. 11. Emission Spectroscopy. 12. Nuclear Magnetic Resonance Spectroscopy. III. SOLUTION BEHAVIOR OF MACROMOLECULES. 13. Macromolecules in Solution: Thermodynamics and Equilibria. 14. Thermodynamics of Transport Processes. 15. Chemical Equilibria Involving Macromolecules. Solutions to Odd-Numbered Exercises. Index.

"As will be seen, there is not much missing here. I thought that the sections were well balanced, with rarely too much or too little on a given topic...This is a text to be welcomed by both teachers and students." BIOCHEMISTRY & MOLECULAR BIOLOGY EDUCATION (on the first edition) The second edition of this successful textbook explains the basic principles behind the key techniques currently used in the modern biochemical laboratory and describes the pros and cons of each technique and compares one to another. It is non-mathematical, comprehensive and approachable for students who are not physical chemists. A major update of this comprehensive, accessible introduction to physical biochemistry. Includes two new chapters on proteomics and bioinformatics. Introduces experimental approaches with a minimum of mathematics and numerous practical examples. Provides a bibliography at the end of each chapter. Written by an author with many years teaching and research experience, this text is a must-have for students of biochemistry, biophysics, molecular and life sciences and food science.

Biological chemistry has changed since the completion of the human genome project. There is a renewed interest and market for individuals trained in biophysical chemistry and molecular biophysics. The Physical Basis of Biochemistry, Second Edition, emphasizes the interdisciplinary nature of biophysical chemistry by incorporating the quantitative perspective of the physical sciences without sacrificing the complexity and diversity of the biological systems, applies physical and chemical principles to the understanding of the biology of cells and explores the explosive developments in the area of genomics, and in turn, proteomics, bioinformatics, and computational and visualization technologies that have occurred in the past seven years. The book features problem sets and examples, clear illustrations, and extensive appendixes that provide additional information on related topics in mathematics, physics and chemistry.

This text surveys the principal physical approaches used to characterize the structure and function of biomacromolecules such as proteins and DNA. It covers spectroscopy, chromatography, mass spectrometry and other topics.

This textbook provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. It is particularly suitable for students planning to enter the pharmaceutical industry. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.