Process Chemistry In The Pharmaceutical Industry
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Process Chemistry in the Pharmaceutical Industry Volume 2
Author | : Kumar Gadamasetti,Tamim Braish |
Publsiher | : CRC Press |
Total Pages | : 520 |
Release | : 2007-12-10 |
Genre | : Science |
ISBN | : 1420008358 |
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As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry in the Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing Climate explores novel applications of synthetic, physical, and analytical chemistry in drug discovery and development. It offers an accurate depiction of the most up-to-date process research and development methods applied to synthesis, clinical trials, and commercializing drug candidates. The second installment in this progressive series, this volumereviews the latest breakthroughs to advance process chemistry, including asymmetric synthesis, crystallization, morphology, enzymatic intervention, green chemistry, macromolecules (monoclonal antibodies, biological molecules, polymers), enantioselectivity, organometallic chemistry, process analytical tools, chemical engineering controls, regulatory compliance, and outsourcing/globalization. It explores new approaches to synthetic processes, examines the latest safety methods and experiment design, and suggests realistic solutions to problems encountered in manufacturing and process development. Significant topics include atom economy, ease of synthesis, instrumentation, automization, quality control, cost considerations, green practices, and future trends. Jointly edited by the founder/president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer, this book brings together contributions byreputed scientists, technologists, engineers, and professors from leading academic institutions, such as the Imperial College, UK, the University of Tokyo, ETH, Switzerland, the International University at Bermen, Germany, and the University of Connecticut, USA, and from principal pharmaceutical companies that include Merck, Bristol Myers Squibb, Pfizer, Novartis, Eli Lilly, Astrazeneca and DSM.
Process Chemistry in the Pharmaceutical Industry
Author | : Kumar G. Gadamasetti,Tamim Braish |
Publsiher | : Unknown |
Total Pages | : 480 |
Release | : 2008 |
Genre | : Chemical processes |
ISBN | : 1628705515 |
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Process Chemistry in the Pharmaceutical Industry Volume 2
Author | : Kumar Gadamasetti,Tamim Braish |
Publsiher | : CRC Press |
Total Pages | : 0 |
Release | : 2007-12-10 |
Genre | : Science |
ISBN | : 0849390516 |
Download Process Chemistry in the Pharmaceutical Industry Volume 2 Book in PDF, Epub and Kindle
As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry in the Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing Climate explores novel applications of synthetic, physical, and analytical chemistry in drug discovery and development. It offers an accurate depiction of the most up-to-date process research and development methods applied to synthesis, clinical trials, and commercializing drug candidates. The second installment in this progressive series, this volumereviews the latest breakthroughs to advance process chemistry, including asymmetric synthesis, crystallization, morphology, enzymatic intervention, green chemistry, macromolecules (monoclonal antibodies, biological molecules, polymers), enantioselectivity, organometallic chemistry, process analytical tools, chemical engineering controls, regulatory compliance, and outsourcing/globalization. It explores new approaches to synthetic processes, examines the latest safety methods and experiment design, and suggests realistic solutions to problems encountered in manufacturing and process development. Significant topics include atom economy, ease of synthesis, instrumentation, automization, quality control, cost considerations, green practices, and future trends. Jointly edited by the founder/president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer, this book brings together contributions byreputed scientists, technologists, engineers, and professors from leading academic institutions, such as the Imperial College, UK, the University of Tokyo, ETH, Switzerland, the International University at Bermen, Germany, and the University of Connecticut, USA, and from principal pharmaceutical companies that include Merck, Bristol Myers Squibb, Pfizer, Novartis, Eli Lilly, Astrazeneca and DSM.
Pharmaceutical Process Chemistry
Author | : Takayuki Shioiri,Kunisuke Izawa,Toshiro Konoike |
Publsiher | : John Wiley & Sons |
Total Pages | : 544 |
Release | : 2010-12-09 |
Genre | : Technology & Engineering |
ISBN | : 9783527633692 |
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Covering the whole area of process chemistry in the pharmaceutical industry, this monograph provides the essential knowledge on the basic chemistry needed for future development and key industrial techniques, as well as morphology, engineering and regulatory compliances. Application-oriented and well structured, the authors include recent examples of excellent industrial production of active pharmaceutical ingredients.
Green Chemistry in the Pharmaceutical Industry
Author | : Peter J. Dunn,Andrew Wells,Michael T. Williams |
Publsiher | : John Wiley & Sons |
Total Pages | : 388 |
Release | : 2010-02-02 |
Genre | : Science |
ISBN | : 3527629696 |
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Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.
Pharmaceutical Process Development
Author | : A. John Blacker,Mike T. Williams,Michael T. Williams,Royal Society of Chemistry (Great Britain) |
Publsiher | : Royal Society of Chemistry |
Total Pages | : 375 |
Release | : 2011 |
Genre | : Medical |
ISBN | : 9781849731461 |
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'Pharmaceutical Process Development' is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry and informs them about the breadth of the work carried out in chemical research and development departments.
Pharmaceutical Process Chemistry for Synthesis
Author | : Peter J. Harrington |
Publsiher | : John Wiley & Sons |
Total Pages | : 815 |
Release | : 2011-02-23 |
Genre | : Science |
ISBN | : 9780470922866 |
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There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.
The Chemistry of Process Development in Fine Chemical and Pharmaceutical Industry
Author | : Someswara Rao |
Publsiher | : John Wiley & Sons |
Total Pages | : 1 |
Release | : 2007-04-02 |
Genre | : Technology & Engineering |
ISBN | : 9780470319956 |
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This book brings together the chemical strategies used in the optimisation of organic reactions and processes, and highlights the practical and technological options available. This book offers: an encyclopedic treatment of organic chemistry from an industrial, process research and development, and manufacturing point of view plenty of examples to illustrate the scope and limitation of the strategies a comprehensive index organised by topic, reaction type, and reagent an extensive literature survey. This is an essential and comprehensive guide for experienced practitioners of chemical process research and development, fresh recruits to chemical industry R&D divisions, and academics who are interested in interacting with the chemical industry, optimising their synthetic strategies, and enriching the field of atom economy.