Puzzling Cases Of Epilepsy

Epilepsy is one of the most common neurological disorders, and original observations in the field are often the key to diagnosis and successful treatment. Physicians new to the field as well as seasoned practitioners will benefit from more than one hundred case vignettes that explore the universe of epilepsy as it presents in daily practice. Some of these cases challenge long-held views about epilepsy and others bring the reader to the limits of our understanding of epilepsy, both in clinical and basic science. To improve the interface of clinical and basic science in epilepsy, basic scientists comment on the potential mechanisms underlying clinical observations, and clinicians assess the potential impact of recent results of experiments in the laboratory. Puzzling Cases of Epilepsy highlights the importance that original observations have in inspiring both new treatments and continued research. Presents unique and challenging case vignettes in epilepsy contributed by eminent physicians in the field Provides practicing physicians with examples of how baffling cases were handled and solved A new section provides a translational perspective, with basic scientists discussing the potential mechanisms underlying original clinical observations, and clinical scientists discussing the clinical implications of experiments in the epilepsy laboratory

'I loved it. She is in my view the best science writer around - a true descendant of Oliver Sacks' Sathnam Sanghera, author of The Boy with the Topknot The brain is the most complex structure in the universe. In Brainstorm the Wellcome Prize-winning author of It’s All in Your Head uncovers the most eye-opening symptoms medicine has to offer. ‘Powerfully life-affirming... Brainstorm is testament to O'Sullivan's unshowy clarity of thought and her continued marvelling at the mysteries of the brain’ Guardian Brainstorm examines the stories of people whose symptoms are so strange even their doctor struggles to know how to solve them. A man who sees cartoon characters running across the room; a teenager who one day arrives home with inexplicably torn clothes; a girl whose world turns all Alice in Wonderland; another who transforms into a ragdoll whenever she even thinks about moving. The brain is the most complex structure in the universe, and neurologists must puzzle out life-changing diagnoses from the tiniest of clues – it’s the ultimate in medical detective work. In this riveting book, one of the UK’s leading neurologists takes you with her as she follows the trail of her patients’ symptoms: feelings of déjà vu lead us to a damaged hippocampus; spitting and fidgeting to the right temporal lobe; fear of movement to a brain tumour; a missed heart beat to the limbic system. It’s a journey that will open your eyes to the unfathomable intricacies of the brain, and the infinite variety of human capacity and experience.

From pediatric to the elderly, from contractible to refractive, epilepsy is an illness that manifests in many forms and across a range of demographics. In this fascinating volume, the author details more than one hundred instances where health care practitioners faced unusual challenges in treating the disease. All aspects of epilepsy are explored through these cases, from the sometimes confusing initial diagnosis to patient responses and treatment methods. In this best-selling short text, the author also presents the lessons learned from these extraordinary cases. 110 Puzzling Cases in Epilepsy is useful for medical students, residents and all health care practitioners, as the practices used to understand these cases can be applied to other diagnoses as well.

From pediatric to the elderly, from contractible to refractive, epilepsy is an illness that manifests in many forms and across a range of demographics. In this fascinating volume, the author details more than one hundred instances where health care practitioners faced unusual challenges in treating the disease. All aspects of epilepsy are explored

“Oliver Sacks meets Stephen King”* in this propulsive, haunting journey into the life of the most studied human research subject of all time, the amnesic known as Patient H.M. For readers of The Immortal Life of Henrietta Lacks comes a story that has much to teach us about our relentless pursuit of knowledge. Winner of the PEN/E.O. Wilson Literary Science Writing Award • Los Angeles Times Book Prize Winner NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Washington Post • New York Post • NPR • The Economist • New York • Wired • Kirkus Reviews • BookPage In 1953, a twenty-seven-year-old factory worker named Henry Molaison—who suffered from severe epilepsy—received a radical new version of the then-common lobotomy, targeting the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry was left profoundly amnesic, unable to create long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today. Patient H.M. is, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves. Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons, as they called themselves, conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide. “An exciting, artful blend of family and medical history.”—The New York Times *Kirkus Reviews (starred review)

Epilepsy is one of the most common disorders of the brain, and these patients often suffer from memory problems. There are a number of reasons for this: seizures can directly affect the brain in ways that disturb memory; epilepsy often results from trouble in brain regions closely linked to memory; the treatment of epilepsy can affect memory; epilepsy can cause psychological problems, like depression, which interfere with memory. The study of epilepsy and the and the study of human memory are interwoven. Epilepsy and Memory comprehensively reviews all aspects of the relationship between this common and potentially serious neurological disorder and memory, one of the core functions of the human mind. The authors, acknowledged experts in their fields, review the history of the subject, the clinical features of memory disorder in epilepsy, neuropsychological, neuroradiological, neuropathological and electrophysiological findings, the roles of anticonvulsant side effects and psychiatric disorder, and the scope for memory support and rehabilitation. The study of patients with epilepsy has revealed much about the workings of memory, yet there has been no recent review of this fertile field of research. This book fills this gap and is a valuable new addition to the brain sciences literature. It will be of wide interest to clinicians and basic researchers in the brain sciences.