Questions Answers About Autoimmunity

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Empowers women to make informed decisions about autoimmune disorders More than 50 million Americans, most of them women, suffer from a constellation of mysterious, often misdiagnosed diseases that can result in disability, disfigurement, and death. Called "autoimmune diseases," they arise when the immune system attacks healthy tissues in almost any area of the body, and include lupus rheumatoid arthritis, Crohn's disease, scleroderma, and Graves' disease. Now Jill Buyon, a doctor working on the cutting edge of research into these diseases, and Rita Baron-Faust, an award-winning medical journalist, arm women with the knowledge they need to obtain accurate diagnoses and the best possible treatments. In The Autoimmune Connection readers learn about the recent groundbreaking discovery of the links between the different autoimmune diseases and why women are more likely to develop them. The authors offer the most up-to-date information on diagnosis, treatments, and risks for women with one or more autoimmune disease.

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

Identify the Cause to Find the Cure Have you been diagnosed with an autoimmune disease—lupus, multiple sclerosis, Crohn’s disease, Grave’s disease, Parkinson’s disease, or one of so many others? Did you know that the root cause of nearly 100 autoimmune diseases is listed as unknown in medical journals? Thankfully, we can look to another source—the Bible—to understand one of the major causes of these diseases. In a clear and straightforward manner, Exposing the Spiritual Roots of Autoimmune Diseases reveals how to identify the root cause and start on the journey toward healing. This is a journey from the inside out. Dr. Henry Wright’s teachings, based on medical findings and powerful biblical truths, affirm that it is God’s will for you to be healthy and whole—in your spirit, soul, and body. If you think you’ve read all you need to know about healing and prevention, it’s time to take another look!

Many of the systemic autoimmune diseases seen in children are different from those seen in adults making them a special problem for physicians and scientists who care for the affected children and study their diseases. Benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties, this volume covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices.

Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markersâ€"sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.