Radiation Dose Reconstruction For Epidemiologic Uses

Growing public concern about releases of radiation into the environment has focused attention on the measurement of exposure of people living near nuclear weapons production facilities or in areas affected by accidental releases of radiation. Radiation-Dose Reconstruction for Epidemiologic Uses responds to the need for criteria for dose reconstruction studies, particularly if the doses are to be useful in epidemiology. This book provides specific and practical recommendations for whether, when, and how studies should be conducted, with an emphasis on public participation. Based on the expertise of scientists involved in dozens of dose reconstruction projects, this volume Provides an overview of the basic requirements and technical aspects of dose reconstruction. Presents lessons to be learned from dose reconstructions after Chernobyl, Three Mile Island, and elsewhere. Explores the potential benefits and limitations of biological markers. Discusses how to establish the "source term"--that is, to determine what was released. Explores methods for identifying the environmental pathways by which radiation reaches the body. Offers details on three major categories of dose assessment.

From 1945 through 1962, the US atmospheric nuclear weapons testing program involved hundreds of thousands of military and civilian personnel, and some of them were exposed to ionizing radiation. Veterans' groups have since been concerned that their members' health was affected by radiation exposure associated with participation in nuclear tests and have pressured Congress for disability compensation. Several pieces of legislation have been passed to compensate both military and civilian personnel for such health effects. Veterans' concerns about the accuracy of reconstructed doses prompted Congress to have the General Accounting Office (GAO) review the dose reconstruction program used to estimate exposure. The GAO study concluded that dose reconstruction is a valid method of estimating radiation dose and could be used as the basis of compensation. It also recommended an independent review of the dose reconstruction program. The result of that recommendation was a congressional mandate that the Defense Threat Reduction Agency (DTRA), a part of the Department of Defense, ask the National Research Council to conduct an independent review of the dose reconstruction program. In response to that request, the National Research Council established the Committee to Review the Dose Reconstruction Program of the Defense Threat Reduction Agency in the Board on Radiation Effects Research (BRER). The committee randomly selected sample records of doses that had been reconstructed by DTRA and carefully evaluated them. The committee's report describes its findings and provides responses to many of the questions that have been raised by the veterans.

Growing public concern about releases of radiation into the environment has focused attention on the measurement of exposure of people living near nuclear weapons production facilities or in areas affected by accidental releases of radiation. Radiation-Dose Reconstruction for Epidemiologic Uses responds to the need for criteria for dose reconstruction studies, particularly if the doses are to be useful in epidemiology. This book provides specific and practical recommendations for whether, when, and how studies should be conducted, with an emphasis on public participation. Based on the expertise of scientists involved in dozens of dose reconstruction projects, this volume: Provides an overview of the basic requirements and technical aspects of dose reconstruction. Presents lessons to be learned from dose reconstructions after Chernobyl, Three Mile Island, and elsewhere. Explores the potential benefits and limitations of biological markers. Discusses how to establish the "source term"â€"that is, to determine what was released. Explores methods for identifying the environmental pathways by which radiation reaches the body. Offers details on three major categories of dose assessment.

In 1997, after more than a decade of research, the National Cancer Institute (NCI) released a report which provided their assessment of radiation exposures that Americans may have received from radioactive iodine released from the atomic bomb tests conducted in Nevada during the 1950s and early 1960s. This book provides an evaluation of the soundness of the methodology used by the NCI study to estimate: Past radiation doses. Possible health consequences of exposure to iodine-131. Implications for clinical practice. Possible public health strategiesâ€"such as systematic screening for thyroid cancerâ€"to respond to the exposures. In addition, the book provides an evaluation of the NCI estimates of the number of thyroid cancers that might result from the nuclear testing program and provides guidance on approaches the U.S. government might use to communicate with the public about Iodine-131 exposures and health risks.

In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.

This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.