Schizophrenia

OPRAH'S BOOK CLUB PICK #1 NEW YORK TIMES BESTSELLER NATIONAL BESTSELLER The heartrending story of a mid-century American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand--even cure--the disease. Don and Mimi Galvin seemed to be living the dream. After World War II, Don's work with the US Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys were diagnosed as schizophrenic. How could all this happen in one family? What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institutes of Mental Health. Their shocking story also offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy and the premise of the schizophrenogenic mother, to the search for genetic markers for the disease, always amidst profound disagreements about the nature of the illness itself. Unknown to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment and even the possibility of the eradication of the disease for future generations. With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love and hope.

Two leading schizophrenia researchers present an accessible and comprehensive guide to dealing with the disease. They provide key information on the integration of drugs and psychological treatments and discuss how family members can be a helpful part of the treatment process.

A concise, up-to-date consumer guide for people who have schizophrenia and their families. An estimated 51 million people worldwide have schizophrenia, 2.2 million of them in the United States. While early diagnosis and appropriate treatment improve the long-term prognosis, schizophrenia is a disease that is difficult to manage. In Living with Schizophrenia, Drs. Jeffrey Rado and Philip G. Janicak, specialists in treating people who have schizophrenia, offer an easy-to-read primer for people with the disorder, along with their families and other caregivers. Drawing on their combined sixty years of clinical and research experience, Drs. Rado and Janicak define schizophrenia and explain what is known about its causes discuss the difference between negative symptoms (such as lack of emotion and social withdrawal) and positive symptoms (such as hallucinations, delusions, and thought disorders) describe medication and psychosocial and behavioral treatments—and the importance of early diagnosis and treatment for better long-term outcomes explain what people with schizophrenia and their families can do to help keep the person well explore how schizophrenia affects the entire family detail medical conditions that people with schizophrenia are more likely than other people to have—including heart disease, obesity, and diabetes offer key takeaway points for every topic Designed for the lay reader and based on the most recent medical literature, Living with Schizophrenia offers information and understanding to help people coping with this often misunderstood disorder to best achieve recovery and healing.

In this book, thirty-five young, recently diagnosed patients speak about schizophrenia and the process of recovery, while two specialists illuminate the medical science, psychoeducation, and therapeutic needs of those coping with the illness, as well as access to medical benefits and community resources. A remarkably inclusive guide, the volume informs patients, families, friends, and professionals, detailing the possible causes of schizophrenia, medications and side effects, the functioning of the brain, and the value of rehabilitation and other services. In their dialogues, participants confront shame, stigma, substance use, and relapse issues and the necessity of healthy eating, safe sex practices, and coping skills during recovery. Clinicians elaborate on the symptoms of schizophrenia, such as violent and suicidal thoughts, delusions, hallucinations, memory and concentration problems, trouble getting motivated or organized, and anxiety and mood disorders. Adopting an uplifting tone of manageability, the participants, authors, and clinicians of this volume offer more than advice--they prescribe hope.

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

This is a series of texts that introduces the reader to some of the more recent advances in schizophrenia research. It is concerned with questioning the role of the immune system in the aetiology and course of the disorder, as well as investigating the efficacy of some of the available treatments for schizophrenia. Edited by a leading scholar in the field, and written by researchers at the cutting edge of these developments, each chapter provides details of original works and their theoretical and empirical impact. The theme of cognition is prevalent throughout the book. As a core deficit in schizophrenia, cognition proves to be fundamental to both the mechanisms underlying the disorder, and the treatments used to alleviate symptomatology. It is evident in all subpopulations of schizophrenia patients explored in this collection -- from those with early onset schizophrenia, to those being treated in forensic mental health services -- and its importance throughout the lifespan of individuals with schizophrenia is highlighted. With a focus on a practical understanding of schizophrenia, this book will be of value to all researchers, psychiatrists and therapists with a clinical or research interest in this subject.