Smart Nanomaterials For Bioencapsulation

Smart Nanomaterials for Bioencapsulation focuses on the fundamentals, synthesis methods and matrix design for the encapsulation of drugs, drug release, food and nutraceuticals, mechanisms of nano- encapsulated drugs on liposomes, micelles, silica composites, carbon nanotubes, dendrimers, and protein inorganic nanohybrids. Providing detailed information on the encapsulation of food and drug derivatives, the book helps create new and modern approaches for both pharmaceutical and nutritional science. The target delivery of pharmacological agents, as well as food additives under various conditions is covered, including sections on systemic release of drug molecules, minimum loss at non-target sites, the accumulation of diseased tissue or organs, and more. Smart nanomaterial-based nanocarriers protect the loaded molecules from premature degradation in the biological environment and enhance bioavailability for cellular uptake. The tuned properties of smart nanomaterials, such as porosity, pore-volume, surface area-to-volume ratio, coating with inert and labile materials, and more help determine the in vivo performance of the bioencapsulated food and drug derivatives. Outlines the major design principles surrounding the encapsulation of drugs, drug release, food and nutraceuticals at the nanoscale Discusses the pros and cons of different bioencapsulation methods for different application areas Outlines the major challenges of applying nanobioencapsulation at an industrial scale

With the start of 2020, the wrath of pandemic challenged the scientific community to develop more advanced drug delivery approaches for biomedical applications, endowing conventional drugs with additional therapeutic benefits and minimum side effects. Although significant advancements have been done in the field of drug delivery, there is a need to focus towards strategizing novel and improved drug delivery systems that should be convenient and cost-effective to the patients, and simultaneously they should also provide financial benefits to pharmaceutical companies. Controlled drug delivery technology offers ample opportunities and scope for improvising the therapeutic efficacy of drugs via optimizing the drug release rate and time. For this endeavour, smart nanomaterials have served as remarkable candidates for biomedical applications, owing to their ground-breaking properties and design. The development of such nanomaterials requires a broad knowledge related to their physio-chemical properties, molecular structure, mechanisms by which the nanomaterials interact with the cells, and methods by which drugs are released at the site of action. This knowledge must also be allied with the knowledge of signaling crosstalk mechanisms that are modulated by the nanomaterial-drugs composite. It can be anticipated that these emerging drug delivery technologies can facilitate the world to successfully encounter such pandemic outbursts in the future in a cost-effective and time-effective manner. The chapters in this book deal with the advanced technologies and approaches that can benefit advanced students, researchers, and industry experts in developing smart and intelligent nanomaterials for future biomedical applications, and development, manufacturing, and commercialization for controlled and targeted drug delivery.

Smart nanomaterials are the basis of diverse emerging applications, and this book covers their technological advances, innovations, and practical applications. It covers advances in the most critical aspects in chemistry and material fabrication of nanomaterials including engineering/prospective applications. The application of smart nanomaterials in the biomedical field, agriculture, food industry, and apparel industry is covered with practical examples. It discusses the future of smart nanomaterials and the pros and cons associated with smart nanomaterials in a detailed manner. Features: Reviews synthesis methods, characterization techniques, and applications of smart nanomaterials. Explores the significance of using smart nanomaterials in futuristic life including examples. Covers bionsensor sensitivity, selectivity, and stability for long-term operation and nanotechnology technique for possibly detecting hazardous viruses. Provides the manufacturing advantages, energy and electronic advantages, medical benefits, environmental effects, and economic issues. Explains risk assessment on humans in detail. This book is aimed at researchers and graduate students in nanomaterials and materials science.

This book highlights the recent advancement in point-of-care testing (POCT) technologies utilizing ‘smart’ nanomaterials for the analysis of biomarkers related to disease, which includes metabolites, enzymes, proteins, nucleic acids, cancer cells and multidrug-resistant pathogen. The POCT refers to medical diagnostic tests performed near the place and time of patient care. During the recent pandemic of COVID-19, many realized the importance of affordable, rapid and accurate POCT devices and their usefulness to combat the spread of the infection. The chapters in this book describe the emergence of ‘smart’ nanomaterials with unique physical and chemical properties being utilized in POCT devices for immobilizing biorecognition elements and labels for signal generation, transduction and amplification. It showcases the applications of these smart nanomaterials and their superiority in developing point-of-care diagnostics devices in a wide range of applied fields like food industry, agriculture sector, water quality assessment, pharmaceuticals and tissue engineering. It also looks into the challenges associated and future direction of research in this promising field. This book caters as reference book for researches from the field of nanobiotechnology and biomedical sciences who are interested in the development of rapid, affordable and accurate POCT devices.

This Research Topic is Volume II of a series. The previous volume, which has attracted over 31k views can be found here: Smart Nanomaterials for Biosensing and Therapy Applications Medicine today faces several challenges when it comes to detecting diseases and prescribing effective treatments, which is crucial for successful disease diagnosis and treatment. Due to their unique structural and functional properties, nanomaterials, which have high surface areas and nanoscale sizes, are gaining wide attention and interest in bioengineering and biotechnology. Compared with bulk materials and molecular molecules, smart nanomaterials with special optical, magnetic, electrical and mechanical properties have shown great potential for biosensing and therapy applications. The development of these smart nanomaterials has created powerful and promising tools to address challenges in conventional diagnostic and therapeutic approaches, such as the lack of diagnostic accuracy and therapeutic efficiency. In the recent past, advances in smart nanomaterials and medical research have opened new possibilities for disease diagnosis and treatment.

The book showcases the newest research on smart nanoplatforms responding to “hypoxia”; an omnipresent pathological feature of many modern-day diseases and its potential applications. The book demonstrates the versatility of hypoxia targeted smart nanoplatforms in disease management in diverse pathological settings presented in chapters contributed by various experts in the field. The themes in the book touch upon critical facets to address pathological hypoxia such as nanomaterials enhancing oxygenation, hypoxia responsive nanoformulations which deliver the drug directly to the hypoxic site, limited toxicity and enhanced efficacy of smart nanoformulations to counter molecular consequences of hypoxia, and theranostics combining hypoxia detection systems with drug delivery systems. This book disseminates the current implications of smart nanomaterials in disease management that can be exploited by scholars, researchers, and pharma industries to develop, manufacture, and commercialize hypoxia targeted diagnostics and therapeutics.

This book covers a number of engineered nanotheranostics platforms and nanomedicines applications of FDA-approved medicines for early-stage diagnosis and treatment of cancer. The book focuses on (i) the basic design and bioengineering of safe medicines, (ii) physicochemical understanding of surface engineered medicines and their characteristics, (iii) various examples for site-specific bioimaging and multimode therapies, (iv) stimuli-responsive approaches for targeted drug delivery applications, (v) targeted therapeutics approaches for cancer cells or solid tumor ablations, (vi) targeted mechanisms of administrative biomedicines, (vii) impact of surface modification or engineering of biomedicines for site-selective tumor binding ability, and (vii) requirements for clinical trials and FDA approval. The content of this book appeal to readers who are interested in recent developments of FDA-approved cost-effective rapid cancer imaging and therapeutic platforms.

Nanotechnology is an emerging, pivotal platform for enhancing plant health. On one hand, nanomaterials serve as crucial nutrients and nanofertilizers, while on the other, they have demonstrated their potential for diagnosing plant diseases, delivering fungicides and pesticides, and providing therapeutic solutions against diseases caused by pathogens and parasites. The book Nanotechnology in Plant Health explores the significance of nanomaterials in plant nutrition, nanofertilizers, and their role in managing plant pathogens, including the most formidable ones like quarantined strains. This unique publication represents a global team of contributors and stands out for its comprehensive coverage of plant nanonutrients, nanofertilizers, and nano-plant protectors.