Systematic

A brilliant young scientist introduces us to the fascinating field that is changing our understanding of how the body works and the way we can approach healing. SYSTEMATIC is the first book to introduce general readers to systems biology, which is improving medical treatments and our understanding of living things. In traditional bottom-up biology, a biologist might spend years studying how a single protein works, but systems biology studies how networks of those proteins work together--how they promote health and how to remedy the situation when the system isn't functioning properly. Breakthroughs in systems biology became possible only when powerful computer technology enabled researchers to process massive amounts of data to study complete systems, and has led to progress in the study of gene regulation and inheritance, cancer drugs personalized to an individual's genetically unique tumor, insights into how the brain works, and the discovery that the bacteria and other microbes that live in the gut may drive malnutrition and obesity. Systems biology is allowing us to understand more complex phenomena than ever before. In accessible prose, SYSTEMATIC sheds light not only on how systems within the body work, but also on how research is yielding new kinds of remedies that enhance and harness the body's own defenses.

How can we identify who benefits from government programs aimed at solving our social problem and who pays for them? With so many problems, how can we allocate scarce funds to promote the maximum well-being of our citizens? In this book, originally presented as the third series of H. Rowan Gaither Lectures in Systems Science at the University of California (Berkeley). Alice M. Rivlin examines the contributions that systematic analysis has made to decisionmaking in the government's "social action" programs—education, health, manpower training, and income maintenance. Drawing on her own experience in government, Mrs. Rivlin indicates where the analysts have been helpful in finding solutions and where—because of inadequate data or methods—they have been no help at all. Mrs. Rivlin concludes by urging the widespread implementation of social experimentation and acceptability by the federal government. The first in such a way as to permit valid conclusions about their effectiveness; the second would encourage the adoption of better ways of delivering services by making those who administer programs responsive to their clients. Underlying both is the requirement from comprehensive, reliable performance measures.

A two-time AJN Book of the Year Award winner and a 2013 Doody Core Title! This distinguished text provides top-tier guidance for advanced practice nurses on how to perform a comprehensive systematic review of available research to inform scholarly work, particularly in DNP and PhD programs. With a strategic focus on the search process and assessing the quality of the evidence, this text presents, clearly and comprehensively, all of the knowledge and skills necessary to conduct a foundational CSR in eight concrete steps. This text examines how to write a CSR proposal, final report, and a policy brief based on systematic review findings. Two finished proposals and two completed systematic reviews demonstrate each step of the process from start to finish. Additionally, the text covers software used in research queries and provides helpful strategies for effectively using the search function when seeking information. The Third Edition offers four new chapters with incisive recommendations for performing a CSR and addressing new ways CSR is being implemented in today’s healthcare environment. It describes the latest methodological advances, including living systematic reviews and dominance scores for economic review. Two complete CSRs along with new and updated examples throughout the book further aid readers in their pursuit of excellence in scholarly work. New to the Third Edition: New Chapters: How to choose the right critical appraisal tool Writing the final report and disseminating the results of systematic reviews Disseminating results with how to write a policy brief and/or press release on CSR results Example of a meta-analysis using GRADE Offers increased focus on dissemination Includes new and updated examples reflecting latest trends in nursing scholarly work Key Features: Provides the knowledge and skills necessary to conduct a CSR from start to finish Teaches readers how to conduct high-quality systematic reviews Instructs readers on pertinent resources and methods for optimal library-related systematic review research efforts Describes how to best search research databases to facilitate scholarly work Includes objectives, summary points, end-of-chapter exercises, discussion questions, suggested reading, and references to enhance understanding

To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.

The original eight volumes now complete and unabridged in four! "Though scholarly in the true sense of the word, this work can also be read and understood by those not formally trained in theology." --Charles C. Ryrie

Focused on actively using systematic review as method, this book provides clear, step-by-step advice on the logic and processes of systematic reviewing. Stressing the importance of precision and accuracy, this new edition carefully balances a need for insightful theory with real-world pragmatism; it introduces a wide range of cutting-edge approaches to research synthesis including text mining, living reviews and new ideas in mixed methods reviews such as qualitative comparative analysis. The book also includes: A new chapter on statistical synthesis Coverage of computer-assisted methods and relevant software Expanded sections on data extraction and management A guide to working with many different types of data including longitudinal and panel. Packed with examples from across the social sciences, this book helps students and researchers alike in turning systematic reviews into recommendations for policy and practice.

Evidence based medicine is at the core of modern medicine. It involves the integration of individual clinical expertise with the best available clinical evidence from systematic research and patient's values and expectations. Systematic reviews offer a summary of the best available evidence. They are the most reliable and comprehensive statement about what works. Written by clinical academics from Australia, UK, USA, and Switzerland, this contributed volume introduces the readers to the principles and practice of systematic reviews and meta-analysis. It covers the various steps involved in systematic reviews including development of a focused question and the strategy for conducting a comprehensive literature search, identifying studies addressing the underlying question, assessment of heterogeneity and the risk of bias in the included studies, data extraction, and the approach to meta-analysis. Crucial issues such as selecting the model for meta-analysis, generating and interpreting forest plots, assessing the risk of publication bias, cautions in the interpretation of subgroup and sensitivity analyses, rating certainty of the evidence using GRADE guideline, and standardized reporting of meta-analysis (PRISMA) are covered in detail. Every attempt is made to keep the narrative simple and clear. Mathematical formulae are avoided as much as possible. While the focus of this book is on systematic reviews and meta-analyses of randomised controlled trials (RCTs), the gold standard of clinical research, the essentials of systematic reviews of non-RCTs, diagnostic test accuracy studies, animal studies, individual participant data meta-analysis, and network meta-analysis are also covered. Readers from all faculties of medicine will enjoy this comprehensive and reader friendly book to understand the principles and practice of systematic reviews and meta-analysis for guiding their clinical practice and research.

First published in 1962, Systematic Politics presents Catlin’s political theories and reviews the work of contemporaries within the field. Divided into two parts, Part One is focused on political science and explores areas such as definitions and functions, the theory of politics as hypothesis, freedom and authority, and different forms of government. Part Two centres on political philosophy, discussing topics such as community, society and the individual, and law and sovereignty. Systematic Politics will appeal to those with an interest in the history of political thought, political theory, and political philosophy.