Tandem Organic Reactions

The importance of tandem reactions is evident--besides their pragmatic value, they have an aesthetic appeal. The author presents a survey of these reactions that will rivet the attention of numerous chemists to their merits and utility as well as stimulate design and discovery of new sets of tandem reactions. Coverage includes Aldol condensation, Michael Reaction, Dieckmann cyclization, thermal and free radical processes, stitching reactions and much more.

Organic Reactions is a comprehensive series devoted to important synthetic reactions, each volume having wide applicability. Each chapter focuses on a single reaction or a definitive phase of a reaction, and each is written by world-renowned chemists with extensive hands-on experience in their specialties. The material is presented from a preparative point of view, and particular attention is given to reaction limitations, interfering influences, effects of chemical structure, and the selection of experimental conditions. Each reaction includes information about its conditions, products, and yields, where available, and is fully referenced to the primary literature. The authors also include detailed procedures illustrating the significant modifications of the chemical reaction, as well as tables featuring all pertinent data about the reaction. Volume 60 contains two chapters: "Epoxide Migration (Payne Rearrangement) and Related Reactions," by Robert M. Hanson, and "The Intramolecular Heck Reaction," by J.T. Link. The most comprehensive and highly focused treatment of important organic reactions currently available, this series represents an important addition to chemistry libraries in both academic and industrial settings, and is a valuable resource for both students and professionals in the field.

The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.

Most reactions in organic chemistry do not proceed in a single step but rather take several steps to yield the desired product. In the course of these multi-step reaction sequences, short-lived intermediates can be generated that quickly convert into other intermediates, reactants, products or side products. As these intermediates are highly reactive, they cannot usually be isolated, but their existence and structure can be proved by theoretical and experimental methods. Using the information obtained, researchers can better understand the underlying reaction mechanism of a certain organic transformation and thus develop novel strategies for efficient organic synthesis. The chapters are clearly structured and are arranged according to the type of intermediate, providing information on the formation, characterization, stereochemistry, stability, and reactivity of the intermediates. Additionally, representative examples and a problem section with different levels of difficulty are included for self-testing the newly acquired knowledge. By providing a deeper understanding of the underlying concepts, this is a musthave reference for PhD and Master Students in organic chemistry, as well as a valuable source of information for chemists in academia and industry working in the field. It is also ideal as primary or supplementary reading for courses on organic chemistry, physical organic chemistry or analytical chemistry.

Organic Reaction Mechanisms 2014, the 50th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2014. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. This volume includes a 5-year cumulative index.

The two-part, fifth edition of Advanced Organic Chemistry has been substantially revised and reorganized for greater clarity. The material has been updated to reflect advances in the field since the previous edition, especially in computational chemistry. Part B describes the most general and useful synthetic reactions, organized on the basis of reaction type. It can stand-alone; together, with Part A: Structure and Mechanisms, the two volumes provide a comprehensive foundation for the study in organic chemistry. Companion websites provide digital models for students and exercise solutions for instructors.

Stereochemistry and Organic Reactions: Conformation, Configuration, Stereoelectronic Effects and Asymmetric Synthesis provides coverage on the stereochemistry of reactions of all mechanistic types, ranging from ionic, pericyclic and transition metal-catalyzed to radical and photochemical. Chapters cover acyclic molecules, cyclic molecules, the stereochemistry of organic reactions, the perturbation molecular orbital theory for the origin of stereoelectronic effects, and an introduction to the principles of stereoselectivity and hierarchical levels of asymmetric synthesis. Each chapter includes problems that reinforce main themes, making it valuable to students, teachers and researchers working in organic, biological and medicinal chemistry, as well as biologists, pharmacologists, polymer chemists and chemists. Presents a holistic and unified approach to stereochemical understanding and predictions, covering reactions of all mechanistic classes Includes two background chapters on perturbation theory and stereoselective principles, along with asymmetric designs Features novel rules and mnemonics to delineate product stereochemistry Includes up-to-date coverage with over 1300 selective references

The 111th volume in this series for organic chemists in academia and industry presents critical discussions of widely used organic reactions or particular steps of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method. Volume contents: RING-OPENING REACTIONS OF EPOXIDES WITH TITANIUM(III) REAGENTS T. V. (Babu) RajanBabu, William A. Nugent, and Sandipan Halder REDUCTIVE CYCLIZATION OF 2-NITRO- AND β-NITROSTYRENES, 2-NITROBIPHENYLS, AND 1-NITRO-1,3-DIENES TO INDOLES, CARBAZOLES, AND PYRROLES Björn C. G. Söderberg and William F. Berkowitz