The Biology Of The Skin

An authoritative, extensively illustrated clinician's textbook, The Biology of the Skin is written expressly for practitioners and residents in dermatology, plastic surgery, and otolaryngology. Essentially an expansion of the editors' and contributing authors' popular "Structure and Function" course given annually at the meetings of the American Academy of Dermatology, the book teaches skin biology in the context of practical clinical settings. This book covers the basic biology of the skin, how the skin functions, effects of the environment, the molecules that direct cutaneous function, genetic influences, and methods in cutaneous research. The Biology of the Skin provides a selective review of all biologic processes involving the skin and will foster an appreciation of how the skin works based on our knowledge of the basic science of skin structure and function in the 21st century.

Molecular Biology of the Skin: The Keratinocyte comprehensively reviews the major aspects of keratinocyte and epidermal differentiation, physiology, and pathology, primarily focusing on the molecular aspects. This exciting new resource discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatological pathology. The volume also highlights areas of genetic disease, new animal models to help in understanding dermatological disorders, and gene therapy using skin as a target. W.W. Franke, a pioneer in the study of the molecular biology of keratins, has written the foreword for the book. Molecular Biology of the Skin: The Keratinocyte is intended for use by dermatologists and basic researchers in cell and developmental biology. It will also be valuable for surgeons and other clinicians as well as researchers in gene therapy, virology, and pharmacology. * * Reviews keratinocyte (and epidermal) differentiation. physiology, and pathology, focusing on the molecular aspects * -Discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatalogical pathology * -Highlights genetic disease, new animal models, and gene therapy

Provides the latest information on imaging technologies and transdermal delivery in skin disorders This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages. It then discusses the key pathways involved in skin growth and development. Clinical presentations, pathophysiological mechanisms, and current clinical practices used to treat diseases affecting the skin are then introduced. Common preclinical models used for studying the mechanisms of diverse skin diseases, validation of novel therapeutic targets, and screening of new drugs to treat these diseases are also covered. The book examines the latest imaging technologies for understanding in vivo skin changes, as well as technologies such as high-resolution ultrasound imaging, quantitative Magnetic Resonance Imaging, high-resolution Optical Coherence Tomography, and emerging hybrid-imaging modalities. It concludes with chapters introducing emerging drug delivery technologies and potential future innovative developments. * Presents up-to-date knowledge of the skin biology and pathologies * Introduces advancements in the topic of imaging technology for tracing the drug delivery process, which is rarely systematically reported by other counterparts * Covers the latest development in three inter-related directions of drug delivery, imaging, and skin disease intersect for skin research * Provides an overview of the latest development of diagnostic and therapeutic technologies for skin diseases Imaging Technologies and Transdermal Delivery in Skin Disorders will be of great interest to analytical chemists, materials scientists, pharmaceutical chemists, clinical chemists, biotechnologists, bioengineers, cosmetics industry, and dermatologists.

This book investigates the social history of skin color from prehistory to the present, showing how our body's most visible trait influences our social interactions in profound and complex ways. The author begins with the biology and evolution of skin pigmentation, explaining how skin color changed as humans moved around the globe. She explores the relationship between melanin pigment and sunlight, and examines the consequences of rapid migrations, vacations, and other lifestyle choices that can create mismatches between our skin color and our environment. Richly illustrated, this book explains why skin color has come to be a biological trait with great social meaning-- a product of evolution perceived by culture. It considers how we form impressions of others, how we create and use stereotypes, how negative stereotypes about dark skin developed and have played out through history. Offering examples of how attitudes about skin color differ in the U.S., Brazil, India, and South Africa, the author suggests that a knowledge of the evolution and social importance of skin color can help eliminate color-based discrimination and racism.

The Structure and Function of Skin, Third Edition is devoted to all matters pertaining to the structure and function of the skin. Drawing upon the accumulated data derived from embryology, histology, anatomy, physiology, biochemistry, and pharmacology, this book presents an overview of skin, with emphasis on human skin. Topics range from the biological functions of the dermis to the histochemical and microchemical properties of the epidermis; the effects of protein deficiency on hair growth; cutaneous innervation; nail regeneration and growth; sebaceous glands; and eccrine sweat glands. This book is organized into 12 chapters and begins with an overview of the structure and function of skin, and then discusses the epidermis and its structural features. Special consideration is given to the life cycle of epidermal cells; the properties and function of stratum corneum; and other cells in the epidermis including melanocytes, the cells of Langerhans, and Merkel cells. The chapters that follow focus on age-related changes in the dermis, cutaneous blood flow, changes in skin circulation, and the dermal nerve network. The book also considers hair growth and differentiation; the effects of malnutrition on the morphology of hair roots; and the structure and development of the nails. A chapter describing the cytochemistry and pharmacology of eccrine sweat glands concludes the book. This book is written primarily for dermatologists, whether seasoned veterans or neophytes, and will also be useful to all biologists who are interested in biomedical disciplines.