Molecular Biology Of The Skin

This acclaimed work has been completely updated to discuss new insights and rapid advances in the molecular biology and physiology of the skin. The section on the immune system has been greatly expanded; a new section on the neurobiology of the skin describes cell-to-cell communication and the expanded role of the Merkel cell, among other topics. This richly illustrated, highly authoritative text is a superb contribution to the literature of dermatological studies.

Molecular Biology of the Skin: The Keratinocyte comprehensively reviews the major aspects of keratinocyte and epidermal differentiation, physiology, and pathology, primarily focusing on the molecular aspects. This exciting new resource discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatological pathology. The volume also highlights areas of genetic disease, new animal models to help in understanding dermatological disorders, and gene therapy using skin as a target. W.W. Franke, a pioneer in the study of the molecular biology of keratins, has written the foreword for the book. Molecular Biology of the Skin: The Keratinocyte is intended for use by dermatologists and basic researchers in cell and developmental biology. It will also be valuable for surgeons and other clinicians as well as researchers in gene therapy, virology, and pharmacology. * * Reviews keratinocyte (and epidermal) differentiation. physiology, and pathology, focusing on the molecular aspects * -Discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatalogical pathology * -Highlights genetic disease, new animal models, and gene therapy

An authoritative, extensively illustrated clinician's textbook, The Biology of the Skin is written expressly for practitioners and residents in dermatology, plastic surgery, and otolaryngology. Essentially an expansion of the editors' and contributing authors' popular "Structure and Function" course given annually at the meetings of the American Academy of Dermatology, the book teaches skin biology in the context of practical clinical settings. This book covers the basic biology of the skin, how the skin functions, effects of the environment, the molecules that direct cutaneous function, genetic influences, and methods in cutaneous research. The Biology of the Skin provides a selective review of all biologic processes involving the skin and will foster an appreciation of how the skin works based on our knowledge of the basic science of skin structure and function in the 21st century.

This Methods in Molecular Biology volume collects reliable protocols covering a wide range of techniques and experimental models, specific molecular assays and disease models, and provides overviews of diagnostic and research topics in molecular dermatology."

This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented. The book focusses especially on: 1. Basic physiology, molecular biology, microstructural and material properties of the skin. 2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches. 3. State-of-the-art constitutive models of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing). 4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology. This book is addressed to postgraduate students in biomedical/mechanical/civil engineering, (bio)physics and applied mathematics, postdoctoral researchers, as well as scientists and engineers working in academia and industry engaged in skin research, particularly, if at the cross-roads of physical experiments, imaging and modelling. The book is also be of interest to clinicians/biologists who wish to learn about the possibilities offered by modern engineering techniques for skin science research and, by so doing, provide them with an incentive to broaden their outlook, engage more widely with the non-clinical research communities and, ultimately, help cross-fertilising new ideas that will lead to better treatment plans and engineering solutions.