The Epidermis In Wound Healing

New biological techniques and a revival of interest in both acute and chronic wound healing have led to an enormously improved understanding of the cellular and chemical complexities of the healing process. Exciting developments in the evolution of epidermal biology are creating new opportunities for research and clinical applications in wound heal

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

- Not only written by experts but the content of each of the chapters has also been peer-reviewed. - Presents a step-by-step approach to the treatment of chronic wounds. - For dermatologists, but also many other medical disciplines such as general practitioners and family physicians who also treat chronic wounds.

This textbook on burn care is focused specifically on the needs of a surgeon. It provides a “how to do” text that presents the practical strategies for initial resuscitation, skin grafting, burn-specific critical care and ultimately guide the surgeon for the best outcomes for the burn surgeon. It provides the reader with basic pathophysiology but avoids a detailed review of the molecular science of burns. Guidelines for basic care with the chapters covering the timeline used for each patient spanning from initial resuscitation (ABCs) to managing their re-socialization are provided. The text covers the key components to the initial management of the burn patient including airway, breathing and circulation. The reader is introduced to the metabolic changes of a major burn and how nutrition and pharmacologic manipulation affects these systemic effects of a burn injury. The management of burn sepsis as well as the basic concepts of wound healing of the different depths and severity of burns are covered. Another chapter covers the basic techniques of skin grafting, rehabilitation and reconstruction with a focus to optimize the cosmetic and functional outcome of the burn. Special chapters cover management of outpatient burns and pediatric injuries. Special burns – electrical, chemical, cold injuries and finally the treatment of other diseases that lead to massive skin loss are covered. Special considerations for pain, scar management, psychosocial recovery, intentional burns, burn prevention and disaster preparation complete the text. Burn Care for General Surgeons and General Practitioners provides a reference for general and plastic surgeons who are planning a career in burns. The textbook will also be a straightforward resource for the general or plastic surgeon who takes care of burns as part of their practice.

A comprehensive resource on the recent developments of stem cell use in wound healing With contributions from experts in the field, Wound Healing offers a thorough review of the most recent findings on the use of stem cells to heal wounds. This important resource covers both the basic and translational aspects of the field. The contributors reveal the great progress that has been made in recent years and explore a wide range of topics from an overview of the stem cell process in wound repair to inflammation and cancer. They offer a better understanding of the identities of skin stem cells as well as the signals that govern their behavior that contributes to the development of improved therapies for scarring and poorly healing wounds. Comprehensive in scope, this authoritative resource covers a wealth of topics such as: an overview of stem cell regeneration and repair, wound healing and cutaneous wound healing, the role of bone marrow derived stems cells, inflammation in wound repair, role and function of inflammation in wound repair, and much more. This vital resource: Provides a comprehensive overview of stem cell use in wound healing, including both the basic and translational aspects of the field Covers recent developments and emerging subtopics within the field Offers an invaluable resource to clinical and basic researchers who are interested in wound healing, stem cells, and regenerative medicine Contains contributions from leading experts in the field of wound healing and care Wound Healing offers clinical researchers and academics a much-needed resource written by noted experts in the field that explores the role of stem cells in the repair and restoration of healing wounds.

On the occasion of the European Congress on Wound Healing and Skin Physiology (Bochum, Germany, November 1992), an international team of scientists and clinicians discussed the core topics in this important field of dermatological and surgical research. Themes include morphology and physiology, microcirculation and angiogenesis, biochemistry and immunology, microbiology and wound infection, non-invasive measurement techniques, wound repair, surgical treatment, dressings, and agents that promote wound healing.

Skin wounds are common occurrences that result from the breakdown of anatomical continuity and integrity of the epidermis, with consequent functional changes. Wound healing is a complex phenomenon through which there is healing of the skin. The wound healing process begins immediately after the wound occurs and can be a lengthy and complex process depending on the severity of the wound and the normal or abnormal healing progress. Wound healing progress through three distinct phases of inflammation, proliferation, and remodeling in a methodical and complex sequence that involves cellular, molecular, and humoral mechanisms of action. Any change in this sequence of events can lead to abnormal wound healing. Due to the health and psychological consequences of wounds that are difficult to heal there has been a continuous effort to develop new therapies that promote wound healing more quickly and effectively and that restore the skin’s barrier function. Nevertheless, this situation remains a medical challenge. This book presents some therapeutic advances based on new and innovative therapeutic options, medical devices, and biomaterials to promote wound healing. It is a theoretical and practical reference for future research on chronic wound healing.