The History Of Scurvy And Vitamin C

This is a survey of the fascinating history of the various ideas and theories causing scurvy.

An intellectual history of scurvy in the eighteenth century Scurvy—a disease usually associated with long stretches of maritime travel—generated extraordinary sensations. Eyes dazzled, skin was morbidly sensitive, emotions veered between disgust and delight. In this book, Jonathan Lamb presents an intellectual history of scurvy unlike any other, probing its cultural impact during the eighteenth-century age of geographic and scientific discovery. Drawing on historical accounts from scientists and voyagers as well as major literary works, Lamb explains the medical knowledge surrounding scurvy and the debates about its cause, prevention, and attempted cures. He argues that a “culture” of scurvy arose in the colony of Australia, which was prey to the disease in its early years, and identifies a literature of scurvy in the works of such figures as Herman Melville, Samuel Taylor Coleridge, Francis Bacon, and Jonathan Swift. Masterful and illuminating, Scurvy shows how eighteenth-century journeys of discovery not only ventured outward to the ends of the earth, but were also an inward voyage into the realms of sensation and passion.

In the Age of Sail scurvy was responsible for more deaths at sea than piracy, shipwreck and all other illnesses, and its cure ranks among the greatest of military successes – yet its impact on history has mostly been ignored. Stephen Bown searches back to the earliest recorded appearance of scurvy in the sixteenth century, to the eighteenth century when the disease was at its gum-shredding, bone-snapping worst, and to the early nineteenth century, when the preventative was finally put into service. Bown introduces us to James Lind, the navy surgeon and medical detective, whose research on the disease spawned the implementation of the cure; Captain James Cook, who successfully avoided scurvy on his epic voyages; and Gilbert Blane, whose social status and charisma won over the British Navy. Scurvy is a lively recounting of how three determined individuals overcame the constraints of eighteenth-century thinking to solve the greatest medical mystery of their era.

Vitamin C is the first book to cover the history, chemistry, biochemistry, and medical importance of vitamin C and is the first to provide an in-depth, interdisciplinary study of this essential and fascinating compound. The book provides a comprehensive and systematic account of the vitamin C story, fully surveying the history of scurvy and how its cure led to the suggestion, discovery, and isolation of the vitamin, later named L-ascorbic acid. It describes in detail the vitamin's structure determination, synthesis and manufacture, and its oxidation products, derivatives and related compounds. Its key biochemical roles are fully categorized and explained, and the medical importance of the vitamin, including the recent use of so-called megadoses, is thoroughly discussed. Vitamin C will be of interest to a very wide readership and will provide useful background information and inspiration for students at various levels. It will also be relevant to the interested chemist or lay person, as well as those carrying out research in this area.

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.

"Provides an up-to-the-minute, comprehensive analysis of the most recent theoretical and clinical developments in vitamin C research--integrating a wide variety of interdisciplinary studies into a single-source volume. Highlights the redox properties of vitamin C, including regeneration, participation in antioxidant networks, and influence on atherosclerosis."

Vitamin C: A 500-Year Scientific Biography from Scurvy to Pseudoscience is the compelling story of the history and science behind vitamin C. Vitamin C begins with scurvy, which afflicted Europe for four hundred years and killed millions. The reasons that a disease whose cure was known from the outset persisted over that time are at once baffling and familiar, and these trials eventually lead to invention of the science of epidemiology. Author Stephen M. Sagar MD then chronicles the discovery of vitamins at the beginning of the twentieth century, a story that encapsulates the rise of a scientific approach to nutrition but with surprising twists and turns. As vitamin science became more acquainted with the mainstream, scientist Linus Pauling reached new heights of fame and influence by popularizing the practice of taking megadoses of vitamin C to prevent colds – a claim that was not necessarily backed by data. This kickstarted the growth of the $40 billion vitamin and supplement industry, which has since prospered all while ignoring science. This unique and engrossing narrative reveals how medical science functions in the real world and how it has changed over the centuries. Featuring swashbuckling sailors, arctic explorers, penny-pinching bureaucrats, academicians with clashing egos, and intrepid scientists working in malaria-infested jungle laboratories, the story of C is in many ways the story of how science gets done (and undone). From the trial and error of early explorers to the scientific breakthroughs made by biochemists and the birth of the modern supplement industry, this revelatory book tells the story of how cherished beliefs, self-interest, and politics often intertwine with scientific progress.