The Innate Immune Response To Noninfectious Stressors

The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans Covers the crucial issue of the immune response to endocrine disruptors Includes immunological parameters as reporter system of environmental adaptation Provides many illustrative examples to foster reader understanding

Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.

The last decade has witnessed the delineation of innate immunity - a new area which has revolutionized our understanding of host-parasite interactions and their impact on defense mechanisms in infectious and noninfectious diseases. This volume of the book series 'Contributions to Microbiology' provides an update of the current knowledge of this expanding field of research and highlights some of its most important aspects. In eleven state-of-the-art articles, eminent international experts in the field address topics such as the innate immune system in mammals and insects, microbial protein ligands, antimicrobial peptides, complement, antibacterial chemokines, the role of neutrophils and monocytes, oxidative innate immune defenses and the effect of aging on innate immunity. The book will be a valuable resource for microbiologists, immunologists, students, scientists of other related disciplines, and clinicians with an interest in infectious or immunological diseases.

Cadmium Toxicity and Tolerance in Plants: Agronomic, Genetic, Molecular and Omic Approaches presents research and latest developments on mechanisms of cadmium tolerance covering both lab and field conditions. This book contains important insights and options for minimizing Cd accumulation in plants and mitigating Cd toxicity. Topics covered include using various omics approaches to understanding plant responses to Cd, novel technologies for developing Cd tolerance and integrated breeding approaches to mitigate Cd stress in crops. Cadmium Toxicity and Tolerance in Plants: Agronomic, Genetic, Molecular and Omic Approaches is a valuable resource for both researchers and students working on cadmium pollution and plant responses as well as related fields of environmental contamination and toxicology. Provides data on mechanisms of cadmium tolerance at the cell, organ and whole plant level Covers several major approaches, molecular and agronomic, in addressing cadmium toxicity in plants and soil Offers real-world, application focused techniques

Wood surface attributes can be established by examining its several different physical or chemical properties. Differences in the wood surfaces occur between the manufacturing and post-treatment processes as well. Understanding how their unique anisotropic molecular organization, chemical linkages, branching, and other molecular features govern micro- and macroscale accessibility is essential for coating and complex modification processes. It is therefore important for scientific as well as practical reasons to qualify and quantify the effects of wood surface treatments and modifications. Challenges still exist to fully understanding the effect of the numerous applied chemicals and the wide range of treatment processes on wood surfaces.

This book describes the importance of sustainable livestock production from a food security perspective in the changing climate scenario. It covers the amelioration of climate change impacts and describes the various mitigation strategies to reduce enteric methane emissions. The book targets sustainable livestock production by covering diverse concepts of amelioration, mitigation, and policy up-gradation. Further, it examines various adverse impacts of climate change on growth, meat, milk, and reproduction in livestock. Most importantly, the book covers novel aspects of quantifying heat stress response of livestock based on non-invasive methodologies, including infrared thermal imaging, sensor-based applications, hair, urine, and fecal cortisol estimation. Particular emphasis was given to describing the skin-based novel approaches to establish climate resilience in indigenous breeds. The book provides detailed descriptions of alleviating climate change impacts on shelter management, nutritional interventions, and genetics-based strategies involving advanced genomic tools. Lastly, it highlights the livestock species which could be considered ideal climate-resilient animal models to withstand the adversities associated with climate change.

Within this book Freya offers practices to help cultivate calm, connection, wonder and well-being. WONDER FULL WOMEN is an acknowledgement and encouragement for women everywhere to recognise our interconnection with our precious planet and all other beings. It is a practical guide that offers ways to eat, move and meditate with the seasons. It gifts us the means to attune and bloom. “This absolute gem of a book does a wonderful job of visiting ancient cultural wisdom and applying it to our modern consuming lives. It is a fantastic resource, providing practical tools for all women, to live a little healthier and perhaps a little happier ” Jane Ferguson, BHSc CM and Nick Conquest, MCM, hosts of the podcast Talking Points with Nick and Jane “A rich and immediately applicable resource for wellbeing, drawing on Freya’s expansive and generous exploration of empowering wellness practices.” Dr Georgie McClean, creative arts and media executive. “This book is full of essential knowledge to live a happy life! Freya speaks from an embodied experience and a kind heart. This compassion comes through in her words and actions. I am so proud to see her joyfully sharing her love of the practice and walking the path. This beautiful book is just another way she is being of service to her family and community.” Dustin Brown, yogi

Previously published as: The Immunological basis of surgical science and practice, 1992.