The Lymphatic System In Colorectal Cancer

The Lymphatic System in Colorectal Cancer: Basic Concepts, Pathology, Imaging, and Treatment Perspectives provides an in-depth overview on the role of the lymphatic system in the pathogenesis and treatment of colorectal cancer. This is the first book to provide a comprehensive, multidisciplinary approach to the lymphatic system in colorectal cancer, with topics ranging from cancer biology and mathematical modeling to surgical approaches and novel imaging techniques. This book is valuable for cancer researchers, oncologists and anyone interested in the biology and treatment of colorectal cancer. Bringing together internationally renowned experts, the book's chapters encompass relevant content to help readers understand complex subjects. Lymphatic spread is one of the hallmarks of locally advanced colorectal cancer that adversely affects prognosis. Nevertheless, the molecular pathogenesis, dynamics and prognostic significance of lymphatic spread remain poorly understood. At the same time, novel surgical approaches such as complete mesocolic excision and sentinel node identification are being introduced, but their value remains uncertain. Presents a multidisciplinary approach, allowing readers to identify relevant fields of collaboration and inspire novel research endeavors in the field Discusses novel imaging techniques such as near-infrared that is being introduced in clinical practice as a tool for identifying sentinel nodes and lymphatic pathways Brings together international experts who shed light on the most relevant aspects of lymphatic spread in cancer of the bowel, underlying mechanisms, and the best method to avoid or treat it

This book details the anatomy and physiology of the lymphovascular system as well as describes the mechanisms of metastasis. It provides readers with an understanding of immune responses of draining lymph nodes against cancer. Coverage also explains the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis.

The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.

Rectal cancer is one of the most prevalent cancers world-wide. It is also a paradigm for multimodal management, as the combination of surgery, chemotherapy and radiotherapy is often necessary to achieve the optimal outcome. Recently, international experts met in Heidelberg, Germany to discuss the latest developments in the management of rectal cancer, including the anatomic and pathologic basis, staging tools, surgical concepts including fast-track surgery and laparoscopic resection, functional outcome after surgery and the role of radio- and chemotherapy. This monograph summarizes this meeting and gives an extensive overview of the current concepts in management of rectal cancer.

Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells. The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi’s sarcoma, and approaches for imaging lymphatics in cancer. The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer. The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis. Key Features: Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process Provides a comprehensive summary of current research in this ground breaking area Provides a book which links progress in basic tumor and developmental biology with current and future oncology practise Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area.

This book provides the most comprehensive and up-to-date knowledge of lymph node micrometastasis (LMM) and sentinel node navigation surgery (SNNS) in gastrointestinal cancers. Lymph node metastasis is a critically important prognostic factor in gastrointestinal tract cancers such as tumors of the esophagus, stomach, and colorectum. An understanding of the basic aspects of lymphatics and lymph nodes, including anatomy, histology, physiology, immunology, and molecular biology, is fundamental for physicians who are involved in cancer treatment. Furthermore, owing to the development of molecular and biological methodology, the precise recognition of LMM and its clinical significance have been clarified recently. At the same time, SNNS has actually been anticipated in treatment of breast tumors, and it is now being introduced in gastrointestinal tract cancer. For the application of SNNS, the detection of lymph node metastasis including LMM is extremely significant, because the presence of LMM determines the direction for surgery and chemo and/or radiation therapy. With these considerations in mind, the expert contributors to this book review basic and clinical approaches for LMM and SNNS including methodology for gastrointestinal cancers. Thus this volume benefits not only surgeons who treat gastrointestinal cancers but also clinical oncologists and medical scientists such as physiologists and pathologists.

Advances in Lymphatic System Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Peyer’s Patches. The editors have built Advances in Lymphatic System Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Peyer’s Patches in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Lymphatic System Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Metastases determine malignancy. The main attention so far has been focused upon organ metastases. The molecular mechanisms thereof, while far from being totally elucidated, are increasingly well understood. Modern diagnostic tools now enable detection and precise localization of small lesions. In contrast, our knowl edge and diagnostic capabilities regarding metastatic spread to the'lymphatic system are rather limited. However, there have re cently been a number of interesting advances. It is the aim of this volume to submit these developments to detailed analysis. The therapeutic relevance of enhanced sensitivity in detection of lymph node metastases has to be considered in the light of in creased morbidity versus eventual prognostic improvements by modification of therapy. An interesting concept which might im prove diagnostic accuracy while reducing operative morbidity is the "sentinel node" technique. Surgical standards are lacking, however, and many fundamental questions pertaining to precise lymphatic mapping remain unanswered. Whether the sentinel node concept is of general relevance or whether it is applicable in only a few organs remains to be determined. This book offers intensive discussion of the concept from methodological and tu mor biological viewpoints. World-renowned experts with long term involvement in related basic and clinical research provide the reader with a broad survey of actual knowledge together with a critical appraisal of recent and future developments. We sincerely hope this book succeeds in providing an outlook as a reference for all clinicians on future prospects and serving and researchers in this extremely important field.