The Notch

Joe Arachro pulled to a halt on a small hillock, looking across the expanse as it rose up into a sudden flat top butte. There was another jagged butte tilting at an angle next to the mesa, not as wide or long. It was like they just appeared from nowhere, dropped down here in the middle of the desert. And in the shimmering glare in the notch between these two buttes, a ten-year-old boy walked out of the sun, surrounded by the blazing rays. The boy doesn't speak, but he has startling powers: he heals a young girl's torn cuticle, and later erases all damage to a man's badly burnt hand, and it seems there's no limit to the miracles he can perform. After a dog gets run over by a car, the boy apparently brings the animal back to life, and a video of the event goes viral. Suddenly everybody has an idea of who the boy is, and what he might do for them -- and it's a race against time to see who can get to the boy first and gain control over him. In the wrong hands, the boy's powers could be catastrophic. From Tom Holland, director and screenwriter of Fright Night and the original Child's Play, comes this new fast-paced thriller with surprises at every turn.

The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research.

Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimer's disease and cerebral arteriopathy CADASIL.

A dark supernatural thriller, based in beautiful and mystical rural Wales, exploring infidelity, betrayal trauma, domestic abuse and murder.