Transfusion Immunology And Medicine

Based on the proceedings of the International Convocation on Immunology held recently at the State University of New York at Buffalo, this up-to-date resource provides a state-of-the-art examination of blood transfusion practice and its future possibilities. Explains the immunological effects of blood transfusion as well as its immunological and

Based on the proceedings of the International Convocation on Immunology held recently at the State University of New York at Buffalo, this up-to-date resource provides a state-of-the-art examination of blood transfusion practice and its future possibilities. Explains the immunological effects of blood transfusion as well as its immunological and microbiological hazards and offers potential remedies!

Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. Consolidates today’s available information on this timely topic into a single, convenient resource.

Describes the immunological aspects of blood transfusion medicine, examining the immuno-chemistry of blood group antigens, the immune destruction of cells, correlations between blood groups and disease, and the effect transfusion-induced retroviral infection has on immune response.

In transfusion medicine the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer, where white cells (WBC) play pivotal roles in this phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer. MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC. UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibody could play an important role in platelet theory. However, the potential infection risks in transfusion like HIV and HCV remain, but application of molecular biological methods like PCR or RT/PCR has great potentials in detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concentrates, like factor IX and protein C, could reduce patients' immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell mediated immune deficiency, as in ADA.

The Diagnostic Standards of Care series presents common errors associated with diagnoses in clinical pathology, using case examples to illustrate effective analysis based on current evidence and standards. In addition to being a practical diagnostic guide, each volume demonstrates the use of quality assurance and the role of the pathologist in ensuring quality and patient safety. Transfusion Medicine addresses common issues and errors seen in the blood transfusion process. The goal is to alert general practitioners and trainees to the latest scientific advances and spiraling regulations in blood transfusion as well as introduce them to the most common types of transfusion errors encountered in clinical settings. Transfusion Medicine features: Descriptions of potential errors in regulatory compliance, operational processes, and patient safety Descriptions of potential errors in clinical decision making in blood transfusion, including when to premedicate patients, warfarin reversal, and the diagnostic intricacies in TRALI and TTP Pocket-sized for portability

“Both authors have dealt in an authoritative way withthe still rapidly expanding specialty and the eleventh edition ofthe book will be of the greatest value to all who are interested inthe scientific and practical aspects of blood transfusion inclinical medicine.” From the Foreword by Professor P.L. Mollison Highly respected, long-established book that has become the"bible" in transfusion medicine Why Buy This Book? Provides a sound basis for understanding modern transfusionmedicine Definitive reference source for any clinician involved withpatients requiring transfusion and for all staff working intransfusion services, immunohaematology laboratories and bloodbanks Highly practical advice on management issues for theclinician Completely revised and updated to reflect the rapid pace ofchange in transfusion medicine Written by two of the world's leading experts in the field

Highly Commended - 2010 BMA Medical Book Awards An essential, practical manual for all those working in transfusion medicine Concise and user-friendly guide to transfusion medicine Focuses on clinical aspects but also covers background science and organizational issues Complications encountered in transfusion are addressed throughout Highlights controversial issues and provides advice for everyday clinical questions in transfusion medicine This comprehensive guide to transfusion medicine takes a practical and didactic approach. The third edition of this text includes many new contributions and has expanded to seven sections. The first of these takes the reader systematically through the principles of transfusion medicine. The second deals with the complications which can arise in transfusion and is followed by a section on the practice of transfusion in blood centres and hospitals. The fourth section covers clinical transfusion practice and the fifth looks at alternatives to transfusion. Section six addresses cellular and tissue therapy and organ transplantation and the final section of the book examines the development of the evidence base for transfusion. As with previous editions; the final section includes a visionary chapter on future advances in the field. This new edition of Practical Transfusion Medicine benefits from even more international authorship than the previous two editions and is an invaluable resource for trainee doctors, scientists, technicians and other staff in haematology and transfusion and as a reference book for clinical staff in haematology and other disciplines faced with specific problems.