Urinary Cytopathology

The first edition of The Paris System for Reporting Urinary Cytology introduced a completely new paradigm for detecting bladder cancer by urine cytology. This system concentrated on defining morphological characteristics of the most clinically significant form of bladder cancer, High Grade Urothelial Carcinoma. This new approach has been widely accepted throughout the world, and has become part of the daily practice of cytology. Considering that the first edition of The Paris System (TPS) introduced a new model of urinary cytodiagnosis, verification and expansion of initial material and data were anticipated. Based on evolving knowledge and readership requests, the group of highly experienced authors have created a new edition of TPS. This second edition includes areas and issues not originally covered. A new chapter on urine cytology of the upper tract, a rarely addressed topic, has been introduced. Furthermore, the issue of cellular degeneration is discussed in the criteria of all diagnostic categories. Examples of standardized reports are included in each chapter. Most importantly, a separate chapter presents data defining the risk of malignancy (ROM) for each diagnostic category to inform clinical management. New high quality images augment those of the first edition to better illustrate diagnostic clues and potential pitfalls. In addition to chapters on diagnostic criteria, current concepts of pathogenesis of bladder cancer, specimen adequacy and preparation, and ancillary tests are covered in separate chapters. A bonus to the volume is a comprehensive history of urine as the earliest diagnostic sample of human disease, richly illustrated with artworks from major museums. Written by internationally recognized authorities, this comprehensive and evidence-based guide to urine cytology is supported by the newest data confirming the original concept and significance of diagnostic criteria defining High Grade Urothelial Carcinoma. TPS is an essential tool for anyone who is practicing urinary cytology, including cytotechnologists, pathologists-in-training and practicing pathologists. This book should find a place in every cytology laboratory throughout the world. The Concept has been endorsed by the American Society of Cytopathology, and the International Academy of Cytology.

"This monograph is intended to serve as a desk reference to help the practicing surgical pathologist implement the 1998 WHO/ISUP classification and to guide the practicing cytopathologist in assessing urinary samples."--p. vii.

Excellent illustrations and the latest technology from the clinic, practice and laboratory are compiled for both the practicing urologist and the researching cytopathologist in the book "Urinary Cytology." The completely revised and up-dated text in the new second edition reflects the first common effort of urologists, pathologists and cytopathologists to find a unified concept: from conventional cytology to electron microscopy toflow cytometry. The authors' main emphasis is on conveying practical techniques for the collection, concentration, fixation, staining and analysis of cellular material. They clearly discuss the circumstances under which new techniques are advisable and the relevance of these techniques when difficult questions of detail arise. At the same time, basic scientific principles arepresented in comprehensible form. The atlas section gives examples of urologic cytology, compares pathological with normal results, discusses the problems in differential diagnosis and points the way to solutions.

This new volume fills the gap in the literature as it will guide urologists and pathologists in the proper utilization of a variety of laboratory methods that are currently available to determine the presence, persistence or progression of tumors of the lower urinary tract. The volume emphasizes cytology of the urinary tract which is preferred over other methods (i.e. biochemical, immunological and cytogenetic) for its accuracy, especially for the important high grade tumors. This volume will appeal to urologists as well as pathologists, cytopathologists and related professions. The illustrations, nearly all in color, stress the key points of the text and enhance basic understanding of urothelial and other tumors of the urinary tract.

Exfoliative and instrumented (catheterized) urines are the most common types of specimens evaluated in a cytology laboratory. The typical clinical presentation is a patient with new onset of urinary symptoms, asymptomatic hematuria, or patient with prior history of urothelial carcinoma on routine surveillance. A careful examination of exfoliated cells from the urinary tract can lead to a fast, relatively simple, economical and accurate cytopathologic diagnosis, which is crucial for timely patient management. However, there are a number of common non-neoplastic reactive conditions that can morp.

• Second volume to be published in the Essentials in Cytopathology series • 125 full-color images • User-friendly and concise guide • Convenient format: Fits in lab coat pocket • 2,000 of the 22,000 practicing pathologists in the US are cytopathologists • 66,000 laboratory technicians deal with urine samples and are potential buyers

Practical Urologic Cytopathology provides the essentials for the cytologic diagnosis of disorders of the urinary tract illustrated with approximately 300 color photomicrographs. The text combines the recent with the classic and standard concepts, particularly in the classification of urothelial tumors. Urothelial tumors are covered contrasting the 1973 and 1999 WHO classification and the 1998 WHO/ISUP (World Health Organization/International Society of Urological Pathologists). The author provides a summary of "key concepts" of each described entity that enhances the practical nature of this book. The book also summarizes the recent developments in the molecular biology and markers for the diagnosis of urothelial tumors and includes chapters on the fine needle aspiration cytopathology of urinary tract masses and on the diagnostic value of urine cytology interpretation. This book is intended for practicing pathologists, pathologists in training, and cytotechnology students as well as researchers and those with special interest in the cytopathology of the urinary tract.

Presents visual and descriptive guidelines for interpreting samples. The book begins with an overview of the urinary system and moves on to the techniques and tools for diagnosing illness, including endoscopy for urologic lesions, urine cytology, bladder biopsies, radiological images of renal lesions, renal mass biopsy, and ancillary tests for urothelial carcinoma.