A Risk Reduction Strategy For Human Exploration Of Space

Extending the spatial and temporal boundaries of human space flight is an important goal for the nation and for the National Aeronautics and Space Administration (NASA). However, human space flight remains an endeavor with substantial risks, and these risks must be identified, managed, and mitigated appropriately to achieve the nation's goals in space. The Bioastronautics Roadmap (BR) is the result of extensive, commendable efforts on the part of NASA to prioritize research efforts to meet these challenges. In 2003, NASA asked the Institute of Medicine (IOM), in collaboration with the Division on Engineering and Physical Sciences of the National Academies, to conduct a review of the BR. Specifically, NASA asked the committee to (1) conduct a comprehensive assessment and report of the strengths and weaknesses of the content and processes of the Bioastronautics Roadmap as applied to the missions described in the President's exploration initiative and (2) identify the unique challenges for accomplishing its goals and objectives. In September 2004, the committee released its preliminary report to NASA entitled Preliminary Considerations Regarding NASA's Bioastronautics Critical Path Roadmap. That document presented the committee's preliminary conclusions about the strengths and weaknesses of the April 2004 version of the BR. This report, A Risk Reductions Strategy for Human Exploration of Space, builds on those preliminary conclusions and provides recommendations to NASA about how to address the issues identified by the committee.

Extending the spatial and temporal boundaries of human space flight is an important goal for the nation and for the National Aeronautics and Space Administration (NASA). However, human space flight remains an endeavor with substantial risks, and these risks must be identified, managed, and mitigated appropriately to achieve the nation's goals in space. The Bioastronautics Roadmap (BR) is the result of extensive, commendable efforts on the part of NASA to prioritize research efforts to meet these challenges. In 2003, NASA asked the Institute of Medicine (IOM), in collaboration with the Division on Engineering and Physical Sciences of the National Academies, to conduct a review of the BR. Specifically, NASA asked the committee to (1) conduct a comprehensive assessment and report of the strengths and weaknesses of the content and processes of the Bioastronautics Roadmap as applied to the missions described in the President's exploration initiative and (2) identify the unique challenges for accomplishing its goals and objectives. In September 2004, the committee released its preliminary report to NASA entitled Preliminary Considerations Regarding NASA's Bioastronautics Critical Path Roadmap. That document presented the committee's preliminary conclusions about the strengths and weaknesses of the April 2004 version of the BR. This report, A Risk Reductions Strategy for Human Exploration of Space, builds on those preliminary conclusions and provides recommendations to NASA about how to address the issues identified by the committee.

As part of the Vision for Space Exploration (VSE), NASA is planning for humans to revisit the Moon and someday go to Mars. An important consideration in this effort is protection against the exposure to space radiation. That radiation might result in severe long-term health consequences for astronauts on such missions if they are not adequately shielded. To help with these concerns, NASA asked the NRC to further the understanding of the risks of space radiation, to evaluate radiation shielding requirements, and recommend a strategic plan for developing appropriate mitigation capabilities. This book presents an assessment of current knowledge of the radiation environment; an examination of the effects of radiation on biological systems and mission equipment; an analysis of current plans for radiation protection; and a strategy for mitigating the risks to VSE astronauts.

As part of the Vision for Space Exploration (VSE), NASA is planning for humans to revisit the Moon and someday go to Mars. An important consideration in this effort is protection against the exposure to space radiation. That radiation might result in severe long-term health consequences for astronauts on such missions if they are not adequately shielded. To help with these concerns, NASA asked the NRC to further the understanding of the risks of space radiation, to evaluate radiation shielding requirements, and recommend a strategic plan for developing appropriate mitigation capabilities. This book presents an assessment of current knowledge of the radiation environment; an examination of the effects of radiation on biological systems and mission equipment; an analysis of current plans for radiation protection; and a strategy for mitigating the risks to VSE astronauts.

This series of reports deals with ongoing research by NASA into a risk reduction strategy for human space exploration and planned manned missions to Mars. Each report deals with a unique aspect of the human research needed to pursue long-duration missions. Many of the reports contain exclusive details about medical events impacting astronauts and cosmonauts on earlier flights, including Mir, Space Shuttle, and ISS Space Station missions. Each risk Evidence Report contains a narrative discussion of the risk and its supporting evidence. All cited publicly-available references are listed at the end of the report. In addition, data that are significant or pivotal are summarized in text, tables, and charts in sufficient detail to allow the reader to critique the data and draw conclusions. The authors also indicate whether the data are from human, animal, or tissue, cellular, or molecular studies. The reports discuss evidence from both spaceflight (including biomedical research, Medical Requirements Integration Document [MRID] data, and operational performance or clinical observations) and ground (including space analog research and non-space analog biomedical or clinical research) research. When providing evidence from ground-based studies, authors discuss why these results are likely to be applicable in the space environment, offering any available validation information for the use of these ground-based systems. Reports included in this compilation: Evidence Book: Risk of Intervertebral Disc Damage * Evidence Report: Risk of Crew Adverse Health Event Due to Altered Immune Response * Evidence Based Review: Risk of Cardiac Rhythm Problems during Space Flight * Evidence Book: Risk of Accelerated Osteoporosis There is a large body of evidence associated with immune dysregulation and spaceflight. However, current studies onboard the International Space Station (ISS) that are defining space normal for the human immune system remain insufficient to determine clinical risk during exploration space missions. In particular, more in-flight studies are needed using human subjects. Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The HRP utilizes various research platforms to conduct research. Ground research occurs in laboratories and analogs that mimic a portion of the spaceflight environment. In addition, the International Space Station (ISS) is used to conduct research requiring the unique environment of space.

In January 2004, President Bush announced a new space policy directed at human and robotic exploration of space. In June 2004, the President's Commission on Implementation of United States Space Exploration Policy issued a report recommending among other things that NASA ask the National Research Council (NRC) to reevaluate space science priorities to take advantage of the exploration vision. Congress also directed the NRC to conduct a thorough review of the science NASA is proposing to undertake within the initiative. In February 2005, the NRC released Science in NASA's Vision for Space Exploration, the first report of the two studies undertaken to carry out these requests. The second report focuses on NASA's plan for the ISS. This report provides broad advice on programmatic issues that NASA is likely to face as it attempts to develop an updated ISS utilization plan. It also presents an assessment of potentially important research and testbed activities that may have to be performed on the ISS to help ensure success of some exploration objectives.