Advances In Functional Micro Nanoimaging Probes

This book highlights the latest advances in functional micro/nano imaging probes and their applications for biomedical imaging and therapy. Given the rapid emergence of transdisciplinary research and applications in materials, chemical probes and translational medicine in recent years, scientists in these areas are expected to keep up to date on the latest technologies and advances to promote comprehensive innovations. Addressing this need, the book presents recently introduced features, emerging techniques, and new strategies, complemented by detailed illustrations. Covering the status quo and offering an outlook on the future, it benefits all readers with an interest in functional materials, especially micro/nano imaging materials for biomedical imaging applications, providing them with both vital updates and inspiration for their own research.

The book sheds light on medical cyber-physical systems while addressing image processing, microscopy, security, biomedical imaging, automation, robotics, network layers’ issues, software design, and biometrics, among other areas. Hence, solving the dimensionality conundrum caused by the necessity to balance data acquisition, image modalities, different resolutions, dissimilar picture representations, subspace decompositions, compressed sensing, and communications constraints. Lighter computational implementations can circumvent the heavy computational burden of healthcare processing applications. Soft computing, metaheuristic, and deep learning ascend as potential solutions to efficient super-resolution deployment. The amount of multi-resolution and multi-modal images has been augmenting the need for more efficient and intelligent analyses, e.g., computer-aided diagnosis via computational intelligence techniques. This book consolidates the work on artificial intelligence methods and clever design paradigms for healthcare to foster research and implementations in many domains. It will serve researchers, technology professionals, academia, and students working in the area of the latest advances and upcoming technologies employing smart systems’ design practices and computational intelligence tactics for medical usage. The book explores deep learning practices within particularly difficult computational types of health problems. It aspires to provide an assortment of novel research works that focuses on the broad challenges of designing better healthcare services.

This book begins by introducing new and unique fabrication, micromachining, and integration manufacturing methods for MEMS (Micro-Electro-Mechanical Systems) and NEMS (Nano-Electro-Mechanical Systems) devices, as well as novel nanomaterials for sensor fabrications. The second section focuses on novel sensors based on these emerging MEMS/NEMS fabrication methods, and their related applications in industrial, biomedical, and environmental monitoring fields, which makes up the sensing layer (or perception layer) in IoT architecture. This authoritative guide offers graduate students, postgraduates, researchers, and practicing engineers with state-of-the-art processes and cutting-edge technologies on MEMS /NEMS, micro- and nanomachining, and microsensors, addressing progress in the field and prospects for future development. Presents latest international research on MEMS/NEMS fabrication technologies and novel micro/nano sensors; Covers a broad spectrum of sensor applications; Written by leading experts in the field.

Synergy is the key to creating more intelligent biosensors. Engineers develop smaller, more integrated technologies; biologists and chemists develop increasingly selective and sensitive sensor elements; material scientists develop ways to bring it all together. However, most books focus only on the chemistry aspects of biosensor technologies. With

Proceedings of SPIE present the original research papers presented at SPIE conferences and other high-quality conferences in the broad-ranging fields of optics and photonics. These books provide prompt access to the latest innovations in research and technology in their respective fields. Proceedings of SPIE are among the most cited references in patent literature.

Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties. Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs Includes over 200 color images to illustrate the power of various nanoimaging technologies Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicine

In this book, the bases of imaging and diffraction in transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM) are explained in the style of a textbook. The book focuses on the explanation of electron microscopic imaging of TEM and STEM without including in the main text distracting information on basic knowledge of crystal diffraction, wave optics, electron lens, and scattering and diffraction theories, which are explained separately in the appendices. A comprehensive explanation is provided on the basis of Fourier transform theory, and this approach is unique in comparison with other advanced resources on high-resolution electron microscopy. With the present textbook, readers are led to understand the essence of the imaging theories of TEM and STEM without being diverted by other knowledge of electron microscopy. The up-to-date information in this book, particularly on imaging details of STEM and aberration corrections, is valuable worldwide for today’s graduate students and professionals just starting their careers.

This book covers preparation methods, characterization, and applications of most glass families. It reports the fundamentals of glass, challenges in the development, traditional and new manufacturing processes, characterization techniques, structural, thermal, and optical properties. The book reviews redox reactions in glasses and the factors affecting them, in addition to the techniques for determining the redox states and speciation of polyvalent ions in glass. A special chapter is dedicate to phosphate glasses, their importance, preparation methods, structure and properties. The use of different types of phosphate glasses in biomedicine, optics, electrochemistry, and as hosts for nuclear wastes is thoroughly discussed. Moreover, the applications of phosphate glasses in electronics and laser technology are also discussed in this book. Recent experimental studies such as the development of a novel bioglass system and the influence of ZnO, TiO2, and Al2O3 incorporation on structural, mechanical strength, degradation, pH variation, and formation of hydroxyapatite (Hap) layer on the glass surface are reported. Promising aluminum-silicate glassy system and its glass-ceramic counterpart are also presented in this books. An overview of the calorimetry approaches related to rare earth improvements on the thermal stability of glass is provided. The book discusses the advances in the chalcogenide glasses (ChGs) and based devices. It also reports their applications in optical devices, semiconductor circuits, and other applications. In addition, lanthanide and/or QDs doped luminescent glasses and their use in solid-state lighting and displays, security (anti-counterfeiting), optical temperature sensors, and solar energy (solar spectrum conversion) are reviewed along with a comparison of their advantages and disadvantages. Finally, the nature of phthalocyanines as materials for glass coatings and most widely used synthesis methods of porphyrins and phthalocyanines are discussed.