Biosensors And Their Applications

A biosensor is a device in which a bioactive layer lies in direct contact with a transducer whose responses to change in the bioactive layer generate eloctronic signals for interpretation. The bioactive layer may consist of membrane-bound enzymes, anti-bodies, or receptors. The potential of this blend of electronics and biotechnology includes the direct assay of clinically important substrates (e.g. blood glucose) and of substances too unstable for storage or whose concentrations fluctuate rapidly. Written by the leading researchers in the field, this book reflects the most current developments in successfully constructing a biosensor. Major applications are in the fields of pharmacology, molecular biology, virology and electronics.

Commercial Biosensors and Their Applications: Clinical, Food, and Beyond offers professionals an in-depth look at some of the most significant applications of commercially available biosensor-based instrumentation in the clinical, food quality control, bioprocess monitoring, and bio threat fields. Featuring contributions by an international team of scientists, this book provides readers with an unparalleled opportunity to see how their colleagues around the world are using these powerful tools. This book is an indispensable addition to the reference libraries of biosensor technologists, analytical chemists, clinical chemists, biochemists, physicians, medical doctors, engineers, and clinical biochemists. The book discusses the need for portable, rapid, and smart biosensing devices and their use as cost-effective, in situ, real-time analytical tools in a variety of fields. Devotes several chapters to applications of biosensors to clinical samples, exploring how biosensors are currently used for in-home diabetes monitoring, point-of-care diagnostics, non-invasive sensing, and biomedical research Includes a section on food applications covering how biosensors can detect genetically modified organisms, toxins, allergens, hormones, microorganisms, species-specificity, pesticides, insecticides, and related components Discusses nanobiosensor and applications, including a chapter on nanotechnological approaches and materials in commercial biosensors

This book broadly reviews the modem techniques and significant applications of chemical sensors and biosensors. Chapters are written by experts in the field – including Professor Joseph Wang, the most cited scientist in the world and renowned expert on sensor science who is also co-editor. Each chapter provides technical details beyond the level found in typical journal articles, and explores the application of chemical sensors and biosensors to a significant problem in biomedical science, also providing a prospectus for the future. This book compiles the expert knowledge of many specialists in the construction and use of chemical sensors and biosensors including nitric oxide sensors, glucose sensors, DNA sensors, hydrogen sulfide sensors, oxygen sensors, superoxide sensors, immuno sensors, lab on chip, implatable microsensors, et al. Emphasis is laid on practical problems, ranging from chemical application to biomedical monitoring and from in vitro to in vivo, from single cell to animal to human measurement. This provides the unique opportunity of exchanging and combining the expertise of otherwise apparently unrelated disciplines of chemistry, biological engineering, and electronic engineering, medical, physiological. Provides user-oriented guidelines for the proper choice and application of new chemical sensors and biosensors Details new methodological advancements related to and correlated with the measurement of interested species in biomedical samples Contains many case studies to illustrate the range of application and importance of the chemical sensors and biosensors

Biosensors are essential to an ever-expanding range of applications, including healthcare; drug design; detection of biological, chemical, and toxic agents; environmental monitoring; biotechnology; aviation; physics; oceanography; and the protection of civilian and engineering infrastructures. This book, like the previous five books on biosensors by this author (and one by the co-author), addresses the neglected areas of analyte-receptor binding and dissociation kinetics occurring on biosensor surfaces. Topics are covered in a comprehensive fashion, with homogeneous presentation for the benefit of the reader. The contributors address the economic aspects of biosensors and incorporate coverage of biosensor fabrication and nanobiosensors, among other topics. The comments, comparison, and discussion presented provides a better perspective of where the field of biosensors is heading. Serves as a comprehensive resource on biosensor analysis Examines timely topics such as biosensor fabrication and nanobiosensors Covers economic aspects and medical applications (e.g., the role of analytes in controlling diabetes)

Advanced Biosensors for Health Care Applications highlights the different types of prognostic and diagnostic biomarkers associated with cancer, diabetes, Alzheimer's disease, brain and retinal diseases, cardiovascular diseases, bacterial infections, as well as various types of electrochemical biosensor techniques used for early detection of the potential biomarkers of these diseases. Many advanced nanomaterials have attracted intense interests with their unique optical and electrical properties, high stability, and good biocompatibility. Based on these properties, advanced nanoparticles have been used as biomolecular carriers, signal producers, and signal amplifiers in biosensor design. Recent studies reported that there are several diagnostic methods available, but the major issue is the sensitivity and selectivity of these approaches. This book outlines the need of novel strategies for developing new systems to retrieve health information of patients in real time. It explores the potential of nano-multidisciplinary science in the design and development of smart sensing technology using micro-nanoelectrodes, novel sensing materials, integration with MEMS, miniaturized transduction systems, novel sensing strategy, that is, FET, CMOS, System-on-a-Chip (SoC), Diagnostic-on-a-Chip (DoC), and Lab-on-a-Chip (LOC), for diagnostics and personalized health-care monitoring. It is a useful handbook for specialists in biotechnology and biochemical engineering. Describes advanced nanomaterials for biosensor applications Relates the properties of available nanomaterials to specific biomarkers applications Includes diagnosis and electrochemical studies based on biosensors Explores the potential of nano-multidisciplinary science to design and develop smart sensing technologies Describes novel strategies for developing a new class of assay systems to retrieve the desired health information

Electrochemical Biosensors summarizes fundamentals and trends in electrochemical biosensing. It introduces readers to the principles of transducing biological information to measurable electrical signals to identify and quantify organic and inorganic substances in samples. The complexity of devices related to biological matrices makes this challenging, but this measurement and analysis are critically valuable in biotechnology and medicine. Electrochemical biosensors combine the sensitivity of electroanalytical methods with the inherent bioselectivity of the biological component. Some of these sensor devices have reached the commercial stage and are routinely used in clinical, environmental, industrial and agricultural applications. Describes several electrochemical methods used as detection techniques with biosensors Discusses different modifiers, including nanomaterials, for preparing suitable pathways for immobilizing biomaterials at the sensor Explains various types of signal monitoring, along with several recognition systems, including antibodies/antigens, DNA-based biosensors, aptamers (protein-based), and more

Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.

Electrochemical Nano-biosensors: Applications in Diagnostics, Therapeutics, Environment, and Food Management features a critical overview of different, recently reported nanomaterial-based electrochemical sensing and biosensing strategies. It is based on various analytical approaches for the point-of-care or POC healthcare related diagnostics, evaluation of contaminants, additives and adulterants in foods and environment management. Each section under the topic is discussed in its exhaustive detail, incorporating significant literature reviews spanning over two decades. The book critically analyzes issues and challenges for its applications in real world settings, universal applicability in resource limited sets-ups of remote areas, ease of integration with other sensing platforms, portability/miniaturization, and more. Takes account of the fact that nanomaterials are increasingly favored as labels for electrochemical immunoassay protocols for the development of highly sensitive and selective electrochemical sensing device Refines biosensors for real-world settings, academicians, healthcare professionals and industrialist who need to team up for the successful realization of POCT/LOCT devices Contains focused and targeted research coupled with other technological advances to help in the development of cutting-edge nanomaterial based electrochemical immunoassays with features of test-strip technology and lateral flow