Fetal Pathology

This book is designed primarily for anatomic pathologists to facilitate their task of accurately diagnosing embryos and fetuses. A detailed examination of the products of spontaneous and induced abortions is necessary for accurate genetic counseling and for establishing the risk for specific abnormalities or another spontaneous pregnancy loss in the future. The growing interest in the defects of early development reflects the profound change in general life-style. In the past, spontaneous abortions were considered a common, usually sporadic event in a patient's reproductive history. Only reassurance and encour agement were given to the patient and scant attention was paid to the detailed pathology of the abortus. Nowadays, however, as a result of reliable methods of contraception and of the availability of reliable prenatal diagnosis for chromosome abnormalities more frequent in advanced maternal age, significant numbers of parents plan to have pregnan cies later in their reproductive life. Consequently, in a case of spontaneous abortion, the question of "cause" and of "future risk" of recurrence of abortion or an abnormal infant is particularly important. In the era of more elaborate and accurate prenatal diagnostic tests, the pathologist examining products of conception has a primary responsibility to detect, in both spontaneous and induced abortions, any developmental abnormality that would indicate an increased risk of multifactorial, chromosomal, and single gene disorders in a subsequent child.

Uniquely authoritative and exhaustively illustrated in color, this atlas provides the clinician with a visual guide to diagnosing congenital anomalies in every organ system in the human fetus.

This book provides a concise guide to fetal pathology and postnatal fetal examination. The legal and ethical aspects of fetal examination are addressed, along with the modern practical approach to fetal malformations, oriented fetal autopsy, neuro-fetopathological examination, and pathology of the placenta. Practical Manual of Fetal Pathology aims to evaluate recent advancements and the impact they have had on clinical practice. This book is relevant to fetal and perinatal pathologists, geneticists, obstetricians, gynecologists, and pediatricians.

This sixth edition provides an overview of fetal and neonatal pathology through a system-based approach. This book contains new chapters on immunology, with a continued focus on molecular aspects of pathology in the perinatal setting. The general principles of perinatal pathology and their clinical situations are also discussed, along with specific pathological entities and their organ systems. Keeling’s Fetal and Neonatal Pathology, sixth edition aims to help the reader treat common problems through anatomical pathology findings and is relevant to practicing and trainee pathologists, obstetricians, maternal and fetal medicine specialists, neonatologists, and pediatricians.

Fetal and Neonatal Pathology presents in one volume an account of the pathological findings encountered when examining fetuses from the second and third trimester of pregnancy as well as in neonatal death. It provides essential clinical and physiological information and discusses the pathogenesis of pathological findings as a guide to the formulation of the appropriate method of investigation. The book is divided into two parts. The first deals with examination of the products of conception after termination of pregnancy for fetal anomaly. The range of pathological abnormality is described and its relevance discussed. Attention is drawn to the differences in pathological findings in specific conditions between the second and third trimester. The second part of the book is system orientated and describes and illustrates those pathological problems which are likely to be encountered in the fetus and neonate. Each chapter is introduced by a concise account of the development of that system. Where relevant there is also discussion of changes at birth as well as changes in normal function that may occur during the neonatal period. Fetal and Neonatal Pathology is primarily written for the morbid anatomist and histopathologist. It also provides a valuable source of reference for obstetricians, neonatologists and paediatricians. Its value as a working tool of reference is enhanced by effective cross-referencing between sections by both chapter and page number. 1

The fourth edition of the classic reference in the field of fetal and neonatal pathology, this revised and updated book retains the overall format of previous editions, presenting the same practical approach to the examination of both fetuses and perinatal deaths. It provides essential clinical and pathophysiological information and discusses the pathogenesis of abnormalities as a basis for appropriate methods of investigation. While primarily addressing the morbid anatomist and histopathologist, it is also a valuable resource for obstetricians, neonatologists and paediatricians.

Describes and illustrates the range of pathological abnormality encountered, whether in spontaneous abortion or following termination for recognized foetal anomaly. A short, didactic account of foetal pathology which should be of interest to all surgical pathology departments.

This comprehensive reference addresses all aspects of fetal and neonatal pathology, including complicated pregnancies, multiple pregnancies, abortion, placental pathology, and disorders affecting the full-term neonate. A consistent organization allows for quick access to specific guidance, and nearly 2,500 illustrations - 2,350 in full color - depict conditions and abnormalities as they present in practice, facilitating diagnosis. An Image Bank on CD-ROM - new to this edition - features all of the illustrations from the 2-volume set, downloadable for presentations. Offers comprehensive coverage of all common and rare embryonic, fetal, and infant disorders in one source. Correlates clinical, pathologic, and genetic findings for each systemic disease. Emphasizes the genetic and molecular basis of birth defects. Features nearly 2,500 illustrations - 2,350 in full color - which depict each abnormality or condition as they present in practice. Presents practical information on autopsy techniques and protocols. Provides the latest guidance on molecular pathology, immunohistochemistry, DNA technology, and more. Offers an expanded discussion of developmental biology related to the pathogenesis of birth defects. Features user-friendly summary tables and diagnostic flow charts, making information quick and easy to find. Includes a CD-ROM featuring all of the illustrations from the 2-volume set.