Nanostructured Materials For Electrochemical Biosensors

Electrochemical biosensors are portable devices that permit rapid analysis of substances. They are most useful in detection and monitoring of biological, chemical and toxic agents. Briefly, with the help of transducer, the generated electrical signals from the responses to change in the bioactive layers are used for the interpretation. Similarly, nanomaterials have number of features that make them ideally suited for sensor applications, such as, its high surface area, high reactivity, easy dispersability and rapid fabrication. This collected work composed of the expert knowledge of many specialists in the construction and use of electrochemical biosensors made of nanostructured materials. This includes nanomaterials such as dendrimers, polymers, nanoparticles, nanotubes, oxides, enzymes and their hybrids as catalyst for various sensors such as glucose sensors, DNA sensors, neurotransmitters sensors, etc. This collected work provides new methodological advancements related to and correlated with the measurement of interested species in biomedical samples. Many studies are also included to illustrate the range of application and importance of the electrochemical biosensors. This provides the unique opportunity for readers to choice a new methods and applications of new electrochemical biosensors.

Providing the unique and vital link between the worlds of electrochemistry and nanomaterials, this reference and handbook covers advances in electrochemistry through the nanoscale control of electrode structures, as well as advances in nanotechnology through electrochemical synthesis strategies. It demonstrates how electrochemical methods are of great scientific and commercial interest due to their low cost and high efficiency, and includes the synthesis of nanowires, nanoparticles, nanoporous and layered nanomaterials of various compositions, as well as their applications -- ranging from superior electrode materials to energy storage, biosensors, and electroanalytical devices.

Electrochemical Biosensors summarizes fundamentals and trends in electrochemical biosensing. It introduces readers to the principles of transducing biological information to measurable electrical signals to identify and quantify organic and inorganic substances in samples. The complexity of devices related to biological matrices makes this challenging, but this measurement and analysis are critically valuable in biotechnology and medicine. Electrochemical biosensors combine the sensitivity of electroanalytical methods with the inherent bioselectivity of the biological component. Some of these sensor devices have reached the commercial stage and are routinely used in clinical, environmental, industrial and agricultural applications. Describes several electrochemical methods used as detection techniques with biosensors Discusses different modifiers, including nanomaterials, for preparing suitable pathways for immobilizing biomaterials at the sensor Explains various types of signal monitoring, along with several recognition systems, including antibodies/antigens, DNA-based biosensors, aptamers (protein-based), and more

Nanotechnology brings new possibilities for the development of sensors, biosensors, and novel electrochemical bioassays. Nanoscale materials have been extensively used in a wide variety of configurations — as electrode surfaces to promote electrochemical reaction, as "wires" to enzymes connecting their redox centers to electrode surface, as nanobarcodes for biomolecules, or as tags to amplify the signal of a biorecognition event. Nanomaterial-based electrochemical sensors have been used in many areas, including cancer diagnostics and the detection of infectious organisms. This book reviews important achievements in the field of nanomaterial-based electrochemical sensors and biosensors.

Novel Nanostructured Materials for Electrochemical Bio-sensing Applications presents a detailed overview into the fabrication of electrochemical bio-sensing devices. The book addresses the challenges and opportunities relating to sustainable and biocompatible sensors from food, water and wearable applications to the various nanostructured biocompatible materials required for sensor fabrication. In addition, it explores the connection between nanomaterials and sensors and takes into consideration different and novel approaches such as toxic materials monitoring and health issues correlated with the use of nanomaterials. Users will find exciting insight into innovations in nanostructured electrochemical biosensing. By providing its audience with fundamentals, limitations, challenges, future perspectives and practical sustainability, this book will serve as a reference source researchers and engineers within analytical chemistry and electrochemistry. Showcases the latest progress in new nanostructured materials, bio-sensing types and applications Provides a comparative vision of electrochemical bio-sensing with other biosensors Discusses the economics, commercialization, toxicity and life line aspects of electrochemical biosensors

Nanomaterials for Biosensors: Fundamentals and Applications provides a detailed summary of the main nanomaterials used in biosensing and their application. It covers recent developments in nanomaterials for the fabrication of biosensor devices for healthcare diagnostics, food freshness and bioprocessing. The various processes used for synthesis and characterization of nanostructured materials are examined, along with the design and fabrication of bioelectronic devices using nanostructured materials as building blocks. Users will find the fundamentals of the main nanomaterials used in biosensing, helping them visualize a systematic and coherent picture of how nanomaterials are used in biosensors. The book also addresses the role of bio-conjugation of nanomaterials in the construction of nano-biointerfaces for application in biosensors. Such applications, including metal nanoparticles, metal oxide nanoparticles, nanocomposites, carbon nanotubes, conducting polymers and plasmonic nanostructures in biosensing are discussed relative to each nanomaterial concerned. Finally, recent advancements in protein functionalized nanomaterials for cancer diagnostics and bio-imaging are also included. Provides a detailed study on how nanomaterials are used to enhance sensing capabilities in biosensors Explains the properties, characterization methods and preparation techniques of the nanomaterials used in biosensing Arranged in a material-by-material way, making it clear how each nanomaterial should be used

As opposed to conventional electrochemical sensors, nanomaterials-based sensors are active and effective in their action with even a minute concentration of analyte. A number of research studies are bringing about an evolution in their development and advancement because of their unique and effective properties. Nanoscale electrochemical sensors have applications in almost every field of life including the detection of neurochemicals, heavy metals, energy components, body fluids, biological matrices, cancer relevant biomolecules, aromatic hydrocarbons, also in playing their role in food science because of their capability in providing quality control and safety. There is a need to develop these nanomaterials-based electrochemical sensors to be more widely available for accurate sensing of minute concentrations especially in the case of heavy metal detection, biofluids, and other biomaterials. This book outlines the major preparation, fabrication and manufacture of nanomaterials-based electrochemical sensors, as well as detailing their principle medical, environmental and industrial applications in an effort to meet this need.This book is a valuable reference source for materials scientists, engineers, electrochemists, environmental engineers and biomedical engineers who want to understand how nanomaterials-based electrochemical sensors are made, and how they are used. Explains the techniques used for the fabrication and manufacture of nanomaterials-based electrochemical sensors Discusses the major applications of nanomaterials-based electrochemical sensors in biomedicine and environmental science Assesses the potential toxicity and other challenges associated with using nanomaterials-based electrochemical sensors

Nowadays, the implementation of novel technological platforms in biosensor-based developments is primarily directed to the miniaturization of analytical systems and lowering the limits of detection. Rapid scientific and technological progress enables the application of biosensors for the online detection of minute concentrations of different chemical compounds in a wide selection of matrixes and monitoring extremely low levels of biomarkers even in living organisms and individual cells. This book, including 16 chapters, characterizes the present state of the art and prospective options for micro and nanoscale activities in biosensors construction and applications.