Nobel Prizes That Changed Medicine

This book brings together in one volume fifteen Nobel Prize-winning discoveries that have had the greatest impact upon medical science and the practice of medicine during the 20th century and up to the present time. Its overall aim is to enlighten, entertain and stimulate. This is especially so for those who are involved in or contemplating a career in medical research. Anyone interested in the particulars of a specific award or Laureate can obtain detailed information on the topic by accessing the Nobel Foundation''s website. In contrast, this book aims to provide a less formal and more personal view of the science and scientists involved, by having prominent academics write a chapter each about a Nobel Prize-winning discovery in their own areas of interest and expertise.

This book brings together in one volume fifteen discoveries that have had a major impact upon medical science and the practice of medicine but where the scientists involved have not been awarded a Nobel Prize. Its aim is to publicize the achievements of these lesser-known heroes of our time and thereby inform and entertain the reader, whether medical student, professor or scientifically-minded layman. Contents:Archibald E Garrod: The Founding Father of Biochemical Genetics (David J Galton)Nikolai Anitschkow: The Birth of the Lipid Hypothesis of Atherosclerosis and Coronary Heart Disease (Daniel Steinberg)Willem-Karel Dicke: The Role of Gluten in Coeliac Disease (Chris J J Mulder and Karel A Dicke)Richard Doll: The Link Between Smoking and Lung Cancer (Tony Seed)Albert Sabin: The Development of an Oral Poliovirus Vaccine (Derek R Smith and Peter A Leggat)René Favaloro: Pioneer of Coronary Artery Surgery (Stephen Westaby)Christiaan Barnard and Norman Shumway: The Heart Transplant Pioneers (Stephen Westaby and David Marais)William Kouwenhoven and Paul Zoll: The Introduction of External Cardiac Massage, Defibrillators and Pacemakers (Max Lab)Inge Edler and Carl Hellmuth Hertz: The Development of Ultrasound for Clinical Use (Bhavna Batohi and Paul S Sidhu)Cyril Clarke, Ronald Finn, John Gorman, Vincent Freda and William Pollack: The Prevention of Rh Haemolytic Disease of the Newborn (David J Weatherall)Herbert Boyer and Stanley Cohen: Recombinant DNA (Anne Soutar)Harvey Alter and Michael Houghton: The Discovery of Hepatitis C and the Introduction of Screening to Prevent Its Transmission in Transfused Blood (Leonard B Seeff and Marc G Ghany)Willem Kolff and Belding Scribner: The Development of Renal Haemodialysis (John Turney)James Till and Ernest Mcculloch: The Discovery of Stem Cells (Joe Sornberger)Akira Endo: The Discovery of Statins (Gilbert Thompson and Hiroshi Mabuchi) Readership: Medical students, professionals and general public. Key Features:This book is the sequel to Nobel Prizes that Changed Medicine. Many of the authors have personal knowledge of the scientists they write about and all are distinguished authorities in their own field. No other book has brought together the non-Nobel Prize-winning discoveries having the greatest influence upon the practice of Medicine, dating from the first description of inborn errors of metabolism by Garrod in 1908 to the discovery of statins, for which Endo received the Lasker Award in 2008Keywords:Inborn Errors;Metabolism;Lipid Hypothesis;Atherosclerosis;Gluten;Coeliac Disease;Smoking;Lung Cancer;Polio Vaccine;Coronary Angiography;Coronary Bypass Grafting;Cardiac Transplantation;Cardiac Massage;Defibrillator;Pace Maker;Ultrasound;Rh Disease;Gene Cloning;Hepatitis C;Haemodialysis;Stem-Cells;Statins

Attributing Excellence in Medicine discusses the aura around the prestigious Nobel Prize in Physiology or Medicine. It analyzes the social processes and contingent factors leading to recognition and reputation in science and medicine. This volume will help the reader to better understand the dynamics of the attribution of excellence throughout the 20th century. Contributors are Massimiano Bucchi, Fabio De Sio, Jacalyn Duffin, Heiner Fangerau, Thorsten Halling, Nils Hansson, David S. Jones, Gustav Källstrand, Ulrich Koppitz, Pauline Mattsson, Katarina Nordqvist, Scott H. Podolsky, Thomas Schlich, and Sven Widmalm.

A part of the Duke Medical Center Library History of Medicine Ephemera Collection.

Originally published in 1990, Nobel Laureates in Medicine or Physiology is a biographical reference work about the recipients of Nobel Prizes in Medicine or Physiology from 1901-1989. Each article is written by an accomplished historian of medicine or science. The book is designed to be accessible to students and general readers as well as to specialists in medical science and history. Each article combines personal and scientific biography, and each has an extensive biography to guide further reading and research.

In The Beginner's Guide to Winning the Nobel Prize, Doherty recounts his unlikely path to becoming a Nobel Laureate. Beginning with his humble origins in Australia, he tells how he developed an interest in immunology and describes his award-winning, influential work with Rolf Zinkernagel on T-cells and the nature of immune defense. In prose that is at turns amusing and astute, Doherty reveals how his nonconformist upbringing, sense of being an outsider, and search for different perspectives have shaped his life and work. Doherty offers a rare, insider's look at the realities of being a research scientist. He lucidly explains his own scientific work and how research projects are selected, funded, and organized; the major problems science is trying to solve; and the rewards and pitfalls of a career in scientific research. For Doherty, science still plays an important role in improving the world, and he argues that scientists need to do a better job of making their work more accessible to the public. Throughout the book, Doherty explores the stories of past Nobel winners and considers some of the crucial scientific debates of our time, including the safety of genetically modified foods and the tensions between science and religion. He concludes with some "tips" on how to win a Nobel Prize, including advice on being persistent, generous, and culturally aware, and he stresses the value of evidence. The Beginner's Guide to Winning the Noble Prize is essential reading for anyone interested in a career in science.

Mary has always wanted to win a Nobel Prize. She loves running her own science experiments at home. But how can she become a real scientist and win the greatest prize of all? One day Mary stumbles on a secret meeting of Nobel Prize winners. Swearing her to secrecy, Professor Barry Marshall agrees to be her guide as she travels around the world and through time to learn the secrets behind some of the most fascinating and important scientific discoveries. They talk space and time with Albert Einstein, radiation with Marie Curie, DNA with Crick, Watson and Wilkins – and much more. Join Mary on her time-travel adventure – and do your own experiments along the way!

In this Brief, Joe Jeffers uncovers the life and works of two-time Nobel Laureate Frederick Sanger. Following Sanger’s early life to retirement, Jeffers describes how this celebrated British biochemist became the first person to determine the amino acid sequence of a protein for which he was awarded the Nobel Prize in 1958. Highlighting Sanger’s remarkable career, Jeffers describes Sanger’s later change in research direction to investigate deoxyribonucleic acids (DNA), work for which Sanger also received the Nobel Prize jointly with Paul Berg and Walter Gilbert in 1980. Joe Jeffers conducted twelve interviews with Sanger over the period of 1999-2009 and he has also spoken to more than 40 of Sanger’s colleagues and family members. This brief provides a rigorous yet concise view of Sanger on a personal and scientific level and is suitable for biochemists, historians or the interested layperson.