Octacalcium Phosphate Biomaterials

Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material. Contains comprehensive, up-to-date information on the basic science, including physical, chemical and biological properties Presents the clinical potential of octacalcium phosphate biomaterials Provides a reference point for new research and increased activity in the area of next generation smarter biomaterials for hard tissue repair and regeneration

The chemistry, structure and biological importance of octacalcium phosphate (OCP) are thoroughly discussed in this volume, which covers a wide scope of topics relevant to the field of calcium phosphates in general. The first chapter reviews the structures of OCP and other important calcium phosphates. It is followed by a description of the mimicry of OCP growth in vivo using in vitro model systems and an extensive review of OCP in biological systems. The remarkable ability of OCP to incorporate biologically relevant organic carboxylates into its structure is also discussed, along with the solubility and surface properties of calcium phosphate salts, and amorphous calcium phosphate and its relationship to OCP. The last chapter centers on the emerging technology of calcium phosphate cements as bone defect repair materials. The book provides in-depth, up-to-date information to all scientists studying calcium phosphate chemistry, biomineralization, pathological calcification, dental caries, biomaterials, and recovery of environmental phosphorus.

Advances in Calcium Phosphate Biomaterials presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and their applications in medicine. It covers the fundamental structures, synthesis methods, characterization methods, and the physical and chemical properties of calcium phosphate biomaterials, as well as the synthesis and properties of calcium phosphate-based biomaterials in regenerative medicine and their clinical applications. The book brings together these new concepts, mechanisms and methods in contributions by both young and “veteran” academics, clinicians, and researchers to forward the knowledge and expertise on calcium phosphate and related materials. Accordingly, the book not only covers the fundamentals but also open new avenues for meeting future challenges in research and clinical applications. Besim Ben-Nissan is a Professor of Chemistry and Forensic Science at the University of Technology, Sydney, Australia

Audience Applied biomathematicians, orthopedists, clinical orthopedists.

Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophosphates. Porous scaffolds made of calcium orthophosphates are very promising tools for tissue engineering applications. A comprehensive overview of calcium orthophosphates, this book highlights their importance and biomedical uses.

This book overviews the underlying chemistry behind the most common and cutting-edge inorganic materials in current use, or approaching use, in vivo.

Reflecting the advances made in recent years, this is a comprehensive overview of calcium orthophosphates for bioceramics and biocomposites with a special focus on the detailed description of all those available, including their biological and geological occurrence, preparation, chemical composition, structure-property relationships and applications. In particular, the book discusses the suitability of these orthophosphates for biomedical applications and their use as bone grafts in surgery and medicine. The result is a useful reference for researchers with an academic, medical or commercial background.

Calcium Phosphates in Biological and Industrial Systems provides a comprehensive discussion on calcium phosphates in the diverse areas of their applications. The authors are all respected specialists in their particular fields, possessing wide knowledge and experience and able to analyze recent results and relate them to their respective areas of expertise. New information, as well as a review of current concepts, highlights the individual contributions. Due to the broad scope of the subject covered and the large number of contributions, this book is divided into three parts. Whilst each section contains a basic theme, there is a considerable overlapping of ideas and approaches. This reflects the excitement and interdisciplinary nature of investigations by researchers interested in dissimilar aspects of calcium phosphates. Considering the general interest in calcium phosphates, Calcium Phosphates in Biological and Industrial Systems is directed at an audience of researchers in the fields of biology, chemistry, dentistry, geology, chemical engineering, environmental engineering, and medicine. It will also be useful to technology-focused researchers in industry whose investigations might be related directly or indirectly to calcium phosphates.