Short Pulse Laser Systems For Biomedical Applications

This book presents practical information on the clinical applications of short pulse laser systems and the techniques for optimizing these applications in a manner that will be relevant to a broad audience, including engineering and medical students as well as researchers, clinicians, and technicians. Short pulse laser systems are useful for both subsurface tissue imaging and laser induced thermal therapy (LITT), which hold great promise in cancer diagnostics and treatment. Such laser systems may be used alone or in combination with optically active nanoparticles specifically administered to the tissues of interest for enhanced contrast in imaging and precise heating during LITT. Mathematical and computational models of short pulse laser-tissue interactions that consider the transient radiative transport equation coupled with a bio-heat equation considering the initial transients of laser heating were developed to analyze the laser-tissue interaction during imaging and therapy. Experiments were first performed to characterize the tissue optical properties needed to optimize the dose for thermal therapy. Experiments were then performed on animal models to characterize the heat affected zone for LITT. The experimental measurements were also validated using the computational models.

This book gives the readers an introduction to experimental and theoretical knowledge acquired by large-scale laser laboratories that are dealing with extra-high peak power and ultrashort laser pulses for research of terawatt (TW), petawatt (PW), or near-future exawatt (EW) laser interactions, for soft X-ray sources, for acceleration of particles, or for generation of hot dense thermal plasma for the laser fusion. The other part of this book is dealing with the small-scale laser laboratories that are using for its research on commercial sources of laser radiation, nanosecond (ns), picosecond (ps), or femtosecond (fs) laser pulses, either for basic research or for more advanced applications. This book is divided into six main sections dealing with short and ultrashort laser pulses, laser-produced soft X-ray sources, large-scale high-power laser systems, free-electron lasers, fiber-based sources of short optical pulse, and applications of short pulse lasers. In each chapter readers can find fascinating topics related to the high energy and/or short pulse laser technique. Individual chapters should serve the broad spectrum of readers of different expertise, layman, undergraduate and postgraduate students, scientists, and engineers, who may in this book find easily explained fundamentals as well as advanced principles of particular subjects related to these phenomena.

The 38 papers contained in this volume are part of the 46 scientific and clinical presentations given at the eighth conference on Ophthalmic Technologies, held 24-25 January, 1998, in San Jose, California. Clinicians, scientists, and engineers came from all regions of the world to attend this meeting, and to present the latest technical advances and clinical results in the field of ophthalmic techniques. This Proceedings is divided into five main oral sections: ophthalmic diagnostics, laser interaction with ocular tissues, ocular surgery, ocular implants, and eye modeling, followed by a sect ion containing poster presentations.

The laser's range of application is extraordinary. Arthur Schawlow says, "What instrument can shuck a bucket of oysters, correct typing errors, fuse atoms, lay a straight line for a garden bed, repair detached retinas, and drill holes in dia monds?"O The laser's specifically biomedical uses cover a similarly broad and interesting spectrum. In this book, I have endeavored to convey some of the fas cination that the laser has long held for me. It is my hope that both clinicians and researchers in the various medical and surgical specialties will find the book a use ful introduction. Biologists, particularly molecular biologists, should also find a great deal of relevant information herein. This volume's distinguished contributors provide admirably lucid discussions of laser principles, instrumentation, and current practice in their respective special ties. Safety, design, capabilities, and costs of various lasers are also reviewed. We have aimed to create a practical text that is comprehensive but not exhaustive. Our emphasis on the practical, rather than the esoteric, is dictated not only by the short history of biomedical laser use, but by the extent of the community to which this information will appeal.

Ultrashort laser pulses with durations in the femtosecond range up to a few picoseconds provide a unique method for precise materials processing or medical applications. Paired with the recent developments in ultrashort pulse lasers, this technology is finding its way into various application fields. The book gives a comprehensive overview of the principles and applications of ultrashort pulse lasers, especially applied to medicine and production technology. Recent advances in laser technology are discussed in detail. This covers the development of reliable and cheap low power laser sources as well as high average power ultrashort pulse lasers for large scale manufacturing. The fundamentals of laser-matter-interaction as well as processing strategies and the required system technology are discussed for these laser sources with respect to precise materials processing. Finally, different applications within medicine, measurement technology or materials processing are highlighted.

This book is a contemporary overview of selected topics in fiber optics. It focuses on the latest research results on light wave manipulation using nonlinear optical fibers, with the aim of capturing some of the most innovative developments on this topic. The book’s scope covers both fundamentals and applications from both theoretical and experimental perspectives, with topics including linear and nonlinear effects, pulse propagation phenomena and pulse shaping, solitons and rogue waves, novel optical fibers, supercontinuum generation, polarization management, optical signal processing, fiber lasers, optical wave turbulence, light propagation in disordered fiber media, and slow and fast light. With contributions from leading-edge scientists in the field of nonlinear photonics and fiber optics, they offer an overview of the latest advances in their own research area. The listing of recent research papers at the end of each chapter is useful for researchers using the book as a reference. As the book addresses fundamental and practical photonics problems, it will also be of interest to, and benefit, broader academic communities, including areas such as nonlinear science, applied mathematics and physics, and optical engineering. It offers the reader a wide and critical overview of the state-of-the-art within this practical – as well as fundamentally important and interesting – area of modern science, providing a useful reference which will encourage further research and advances in the field.