Systems Biology in Toxicology and Environmental Health

Systems Biology in Toxicology and Environmental Health
Author: Rebecca Fry
Publsiher: Academic Press
Total Pages: 284
Release: 2015-06-11
Genre: Medical
ISBN: 9780128015681

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Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health. Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them

Environmental Health Perspectives

Environmental Health Perspectives
Author: Anonim
Publsiher: Unknown
Total Pages: 102
Release: 1993
Genre: Environmental health
ISBN: MINN:30000010711574

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Environmental Genomics

Environmental Genomics
Author: C. Cristofre Martin
Publsiher: Springer Science & Business Media
Total Pages: 363
Release: 2008-01-18
Genre: Science
ISBN: 9781588297778

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Here is a manual for an environmental scientist who wishes to embrace genomics to answer environmental questions. The volume covers: gene expression profiling, whole genome and chromosome mutation detection, and methods to assay genome diversity and polymorphisms within a particular environment. This book provides a systematic framework for determining environmental impact and ensuring human health and the sustainability of natural populations.

The Exposome

The Exposome
Author: Gary W. Miller
Publsiher: Academic Press
Total Pages: 298
Release: 2020-06-17
Genre: Science
ISBN: 9780128140796

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The Exposome: A New Paradigm for the Environment and Health, Second Edition, is a thoroughly expanded and updated edition of The Exposome: A Primer, the first book dedicated to the topic. This new release outlines the purpose and scope of this emerging field of study, its practical applications, and how it complements a broad range of disciplines. The book contains sections on -omics-based technologies, newer detection methods, managing and integrating exposome data (including maps, models, computation and systems biology), and more. Both students and scientists in toxicology, environmental health, epidemiology and public health will benefit from this rigorous, yet readable, overview. This updated edition includes a more in-depth examination of the exposome, including full references, further reading and thought questions. Addresses an emerging field that connects with other exciting disciplines Written by a single author who is a leader in the field Includes new content that widely expands on the first edition

Hormesis

Hormesis
Author: Mark P. Mattson,Edward J. Calabrese
Publsiher: Humana Press
Total Pages: 0
Release: 2014-11-26
Genre: Medical
ISBN: 1627038515

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Hormesis is a poorly understood phenomenon affecting all forms of life on earth. This groundbreaking book summarizes and analyzes the various positives of hormesis in an attempt to reveal hormesis as a fundamental principle of biomedical sciences as a whole.

Toxicity Testing in the 21st Century

Toxicity Testing in the 21st Century
Author: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents
Publsiher: National Academies Press
Total Pages: 217
Release: 2007-11-05
Genre: Nature
ISBN: 9780309151733

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Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Computational Toxicology

Computational Toxicology
Author: Sean Ekins
Publsiher: John Wiley & Sons
Total Pages: 856
Release: 2007-06-30
Genre: Science
ISBN: 9780470145883

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A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with: * An introduction to toxicology methods and an explanation of computational methods * In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels * Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena * Chapters written by leading international experts * Figures that illustrate computational models and references for further information This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.

Biologic Markers in Reproductive Toxicology

Biologic Markers in Reproductive Toxicology
Author: National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Reproductive and Neurodevelopmental Toxicology
Publsiher: National Academies Press
Total Pages: 424
Release: 1989-02-01
Genre: Social Science
ISBN: 0309039797

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Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markersâ€"indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive abilityâ€"are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.