The Human Fragment

Nonfiction. Photography. "[Michael Ernest Sweet] is a genius at composition, finding the beauty in the shapes and surprises of everyday life. His works often look set up and arranged, but in reality they're capturing the stylistic sexiness of the urban jungle as it pops up in spontaneous ways that only a photo could let you ponder and dissect." Michael Musto, from the Foreword"

Published in 1904 (CW 10) "Not everyone can immediately achieve spiritual vision; but the discoveries of those who have it can be health-giving life nourishment for all. The results of supersensible knowledge, when properly employed in life, prove to be not impractical, but rather, practical in the highest sense.... The acquisition of higher knowledge is not the end, but the means to an end; the end consists in the attainment, thanks to this knowledge, of greater and truer self-confidence, a higher degree of courage, and a magnanimity and perseverance such as cannot, as a rule, be acquired in the lower world." This is the classic account of the modern Western esoteric path of initiation made public by Steiner in 1904. He begins with the premise that "the capacities by which we can gain insights into the higher worlds lie dormant within each one of us." Steiner carefully and precisely leads the reader from the cultivation of the fundamental soul attitudes of reverence and inner tranquility to the development of inner life through the stages of preparation, illumination, and initiation. Steiner provides practical exercises of inner and outer observation and moral development. By patiently and persistently following his guidelines, new "organs" of soul and spirit begin to form, which reveal the contours of the higher worlds thus far concealed from us. Steiner in this important work becomes a teacher, a counselor, and a friend whose advice is practical, clear, and effective. The challenges we face in life require increasingly deeper levels of understanding, and Steiner's text helps readers to cultivate the capacities for such insights and places them at the service of humanity. This is Steiner's most essential guide to the modern path of initiation he advocated throughout his life. It has been translated into many languages and has inspired hundreds of thousands of readers around the world. How to Know Higher Worlds has been admired by some of the most brilliant minds of our time. "The methods by which a student is prepared for the reception of higher knowledge are minutely prescribed. The direction he is to take is traced with unfading, everlasting letters in the worlds of the spirit where the initiates guard the higher secrets. In ancient times, anterior to our history, the temples of the spirit were also outwardly visible; today, because our life has become so unspiritual, they are not to be found in the world visible to external sight; yet they are present spiritually everywhere, and all who seek may find them." Knowledge of the Higher Worlds and Its Attainment is a translation from German of the written work Wie erlangt man Erkenntnisse der höheren Welten? (GA 10).

The universe may well have begun with an immense act of fragmentation, "the big bang," that sent particles flying in all directions to perform spectacular acts of creation and destruction. The fragment, volatile and unpredictable, is not simply the static part of a once-whole thing but itself something in motion. Drawing upon art history, archaeology, literature, numismatics, philosophy, and film, this book explores the significance of the fragment and addresses the powerful drives that have impelled it into the cultural mainstream. Book jacket.

Part 2 covers the junctures between the body's "outside" and "inside" by studying the manifestations - or production - of the soul and the expression of the emotions and, on another level, by examining the speculations inspired by cenesthesia, pain, and death.

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

Answering the need to facilitate quantum-chemical calculations of systems with thousands of atoms, Kazuo Kitaura and his coworkers developed the Fragment Molecular Orbital (FMO) method in 1999. Today, the FMO method can be applied to the study of whole proteins and protein-ligand interactions, and is extremely effective in calculating the propertie