Viral Hepatitis Molecular Biology Diagnosis And Control

The last forty years have witnessed the discovery of five human hepatitis viruses: hepatitis virus A, B, C, D, and E, and two related blood-borne viruses: GB virus C and TT virus. Viral Hepatitis provides a comprehensive overview of the latest developments and research studies in human viral hepatitis. Written by leading international scientists in the field, this book covers topics ranging from the history of these viruses to their molecular biology, diagnosis, epidemiology and control. It will be an invaluable reference source for hepatitis researchers, reference and diagnostic laboratories, clinicians, public health officers and graduate and medical students. Book jacket.

This book aims to bridge the widening rift between clinical and molecular aspects of viral hepatitis by providing an up-to-date overview of the field. The focus is practical and covers the limitations of clinical diagnosis, the interpretation of tests bas

Hepatitis A and B viruses have infected nearly half the current world population; and as many as 500 million people are still infected with the hepatitis B or C virus today. Hepatitis B vaccination is effective but not universally adopted and no vaccine is available against hepatitis C. Treatment is prohibitively expensive for areas of high endemicity or prevalence and not universally effective. This important and timely book covers recent advances in understanding the molecular biology of hepatitis viruses. The advances have contributed new insights into the molecular mechanisms involved in replication of genetic information and in gene expression; and have translated into diagnostics; prevention and development of antiviral drugs. Contents:Hepatitis A VirusHepatitis B VirusHepatitis Delta VirusHepatitis C VirusHepatitis E VirusOther Hepatitis-Associated Viruses: HGV/GBC Readership: Graduate students; virologists (medical/non-medical) and molecular biologists. Keywords:Viral Hepatitis;Hepatitis A;Hepatitis B;Hepatitis C;Hepatitis D;Delta Virus;Non-A Non-B Hepatitis;Hepatocellular Carcinoma;Viral CarcinogenesisReviews: “It is a sound accompaniment to a focussed lecture; a bookshelf reference on this group of viruses in one volume; but moreover; a detailed introduction to the nucleic acid arrangements of these diverse pathogens.” Australian Journal of Medical Science “This book provides a good introduction and foundation for the study of this disparate group of viruses and the low price will make it readily accessible to students of microbiology; virology and medicine.” Microbiology Today

This series is designed to bridge the gap between pure research in the biomedical sciences and its practical application in clinical medicine. The objective is to promote the understanding of the molecular basis of human physiology and disease, and new techniques for diagnosis and treatment. Primarily intended for graduate students of medicine, the books will also be of use to molecular biologists, biochemists, physiologists, pharmacologists and biotechnologists, as well as medical practitioners and technicians who seek to update their knowledge. The Molecular Medicine of Viral Hepatitis Edited by Tim J. Harrison and Arie J. Zuckerman Royal Free Hospital School of Medicine, London, UK General texts on diagnostic and clinical aspects of viral hepatitis abound. The Molecular Medicine of Viral Hepatitis focuses on those areas of research where advances are presently being mode and offers new ideas on the development of vaccines, diagnostic tests and therapeutic agents. Chapters include: The molecular biology of attenuation of hepatitis A virus Development of vaccines against hepatitis E virus infection The molecular role of hepatitis B virus in the development of hepatocellular carcinoma Genotypes and genetic variation of hepatitis C virus As such this volume will be indispensable to clinicians and researchers in virology, hepatology, microbiology, vaccinology, oncology and gastroenterology.

Cutting-edge collection of reviews and articles on HBV and HCV, as well as new emerging hepatitis viruses. Subjects include regulatory issues, epidemiology, emerging viruses, immunology, vaccines, pediatric HBV and HCV, genetics, pathology, viral diagnosis, cell systems, animal models, drug discovery and development, and prevention and treatment options for hepatocellular carcinoma. Book jacket.

Molecular diagnostic procedures have been described in a number of recent books and articles. However, these publications have not focused on virus detection, nor have they provided practical protocols for the newer molecular methods. Written by the inventors or principal developers of these technologies, Molecular Methods for Virus Detection provides both reviews of individual methods and instructions for detecting virus nucleic acid sequences in clinical specimens. Each procedure includes quality assurance protocols that are often ignored by other methodology books. Molecular Methods for Virus Detection provides clinically relevant procedures for many of the newer diagnostic methodologies. Provides state-of-the-art PCR methods for amplification, quantitation, in situ hybridization, and multiplex reactions Goes beyond PCR with protocols for 3SR, NASBA, LCR, SDA, and LAT Covers important virus detection methods such as in situ hybridization; Southern, dot, and slot blots; branched chain signal amplification; and chemiluminescence Includes quality control information crucial in research and clinical laboratories Most chapters are written by the inventors and principal developers of the methodologies Includes color plates, 77 figures, and 18 tables

There has been an explosion of both the incidence and medicalknowledge of viral hepatitis over the last two decades. Not only isthe incidence of infection and disease increasing, but newhepatitis viruses have been discovered, as well as the launch ofnew pharmaceutical products. Previously published by Churchill Livingstone, ViralHepatitis by Zuckerman & Thomas was the first comprehensivebook on hepatitis and is recognized as the standardreference text in this field. The new third edition, now published by Blackwell Publishing,addresses the recent advances in diagnosis and treatment withentirely revised and current topics. It covers the entire spectrumof viral hepatitis and has something of interest for everyspecialist. Viral Hepatitis presents the latest thinking from theleading international researchers and clinicians working in thisfield and the Editors are joined by a North American co-Editor forthis edition - Professor Stanley Lemon of the University of Texas,Galveston, TX, USA. This book offers an ideal reference for all healthcareprofessionals involved in the research and patient care of thisdisease.

Molecular Biology of the Hepatitis B Virus presents a comprehensive account of the various molecular aspects of the life cycle of the hepatitis B virus (HBV). Topics covered include the animal model systems, sequence data on the hepadnavirus genomes, the transcripts coded for the biral genome and sequence elements involved in regulating their expression, hepadnavirus replication, and analysis of the various HBV gene products and their role in virion synthesis and assembly. Other important features of the book include its discussions of the consequences of long term exposure to hepadnavirus infection and its association with hepatocellular carcinoma, the use of recombinant technologies in the generation of second generation vaccines, and the utilization of recombinant technologies to analyze an immune mediated disease. Researchers studying hepadnaviruses will find a wealth of information in this essential reference volume.