Biological Interactions With Surface Charge In Biomaterials

This book is the first to comprehensively address the complex phenomenon of biological interactions with the surface charge of biomaterials.

Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.

At the interface of biology, chemistry, and materials science, this book provides an overview of this vibrant research field, treating the seemingly distinct disciplines in a unified way by adopting the common viewpoint of surface science. The editors, themselves prolific researchers, have assembled here a team of top-notch international scientists who read like a "who's who" of biomaterials science and engineering. They cover topics ranging from micro- and nanostructuring for imparting functionality in a top-down manner to the bottom-up fabrication of gradient surfaces by self-assembly, from interfaces between biomaterials and living matter to smart, stimuli-responsive surfaces, and from cell and surface mechanics to the elucidation of cell-chip interactions in biomedical devices. As a result, the book explains the complex interplay of cell behavior and the physics and materials science of artificial devices. Of equal interest to young, ambitious scientists as well as to experienced researchers.

Given such problems as rejection, the interface between an implant and its human host is a critical area in biomaterials. Surfaces and Interfaces for Biomaterials summarizes the wealth of research on understanding the surface properties of biomaterials and the way they interact with human tissue. The first part of the book reviews the way biomaterial surfaces form. Part Two then discusses ways of monitoring and characterizing surface structure and behavior. The final two parts of the book look at a range of in vitro and in vivo studies of the complex interactions between biomaterials and the body. Chapters cover such topics as bone and tissue regeneration, the role of interface interactions in biodegradable biomaterials, microbial biofilm formation, vascular tissue engineering and ways of modifying biomaterial surfaces to improve biocompatibility. Surfaces and Interfaces for Biomaterials will be a standard work on how to understand and control surface processes in ensuring biomaterials are used successfully in medicine.

An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures. Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body’s wound-healing response is emphasized throughout. Specific topics covered include:Structure and properties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix. Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today’s and tomorrow’s implantable biomedical devices.

A succinct handbook explaining interdisciplinary processing, methods, and applications of bio-based materials This book merges the two most important trends in biomaterials: functionalization and renewable chemistry. It covers a variety of biopolymers and various approaches for the transformation of these biopolymers into functional units. Sample topics covered by the two well-qualified authors include: Fundamental knowledge of biopolymers–natural ones, such as cellulose and other polysaccharides, and synthetic ones, such as polyethylene The origin, classifications, chemical nature, and isolation methods of specific biopolymers The different classical and modern approaches for the transformation of biopolymers into different shapes, ranging from thin films (model surfaces), to nanoparticles, to nanofibers, all the way to 3D scaffolds The morphology, structure, shape, thermal, electrical, and surface properties of biomaterials This all-inclusive reference guide, which covers fundamentals, methods, and applications alike, is a key resource for both students and practicing scientists involved in programs of study or disciplines that intersect with the field of biomaterials.

Stress induced electrical charges, action potential and electret behavior of bone, muscles, skin and nerve cells have been known for some time. Electrically Active Materials for Medical Devices builds on this knowledge and encourages readers to understand and exploit electrical activity in biomaterials from native, derived, or completely synthetic origin, or a combination thereof. It presents data and insights from both historic and contemporary research that spans over six decades with a view to generate convergence of interdisciplinary knowledge and skills. Divided into four parts, this book first introduces the reader to a general overview of electrically active materials in biology and biomedical science and describes important concepts and pioneering discoveries. The second part discusses common types of materials that are known to generate electrical activity and lays the foundation for these materials for use in medical devices. The third part gives examples of where electrically active materials have been examined for device application. The final part looks for upcoming and emerging concepts, tools and methodologies that are expected to shape the future profile of this field of converging science. Written by specialists in their respective fields, it has been specifically targeted at a readership of professionals, graduate students and researchers in the fields of biomedical engineering, physics, chemistry biology and clinical medicine.

With development of implants and in vivo detection devices comes the complication of the interaction between the materials used in the devices and biological fluids. This book examines these interactions causing fouling in biosensors and the serious issue of thrombus formation. The chemistry of surface-protein and surface-cell interactions is considered, the coatings and strategies re the avoidance of fouling are compared and the expert contributors provide a comprehensive look at the physical chemistry of the implant surface and the fouling problem. Finishing with a discussion of the future for surface modified biosensors in point-of-care devices and microfluidic technologies, this book provides an important addition to the literature suitable for professional researchers in academia and industry and postgraduate students.