Membrane Bioenergetics

Membrane bioenergetics is one of the most rapidly growing areas within physico-chemical biology. Main aspects treated in this book include energy conservation and utilization by membrane-linked molecular mechanisms such as intracellular respiration, photosynthesis, transport phenomena, rotation of bacterial flagella, and the regulation of heat production.

Energy Transduction in Biological Membranes was primarily designed for graduate courses in bioenergetics. Not only does it discuss basic principles and concepts central to modern membrane biochemistry, biophysics and molecular biology, but also (1) the components and pathways for electron transport and hydrogen ion translocation, and (2) the utilization of electrochemical ion gradients. The book is unique in presenting a comparative treatment of respiratory and photosynthetic energy transduction, and in using protein sequence data coupled with physical concepts to discuss the mechanisms of energy transducing proteins.

This book is formulated from the papers presented at the International Symposium on "Membrane Biochemistry and Bioenergetics," held at the Rensselaerville Institute, Rensselaerville, New York, August 1986, in honor of Tsoo E. King on the occasion of the 30th anniversary of reconstitution of arespiratory chain system by Professor David Keilin and Tsoo E. King. Professor Tsoo E. King, to whom this volume is dedicated, has made enormous contributions to the field of isolation and reconstitution of membrane proteins and has continued to explore the frontiers of bioener getics. In particular, his persistent proposals on the existence of ubiquinone binding proteins from conceptualization to experimentation eventually convinced many scientists to study these proteins further . Professor King's preparation of reconstitutively active succinate dehydrogenase opened a new avenue in the fie1d of membrane bioenergetics, and his work has been greatly appreciated. The purpose of the symposium was to bring together scientists from diverse disciplines related to membrane bioenergetics to discuss the recent developments in the field. This symposium, initiated by the Capital District Bioenergetics Group, was attended by 100 scientists, 80 of whom presented their recent discoveries. The symposium was arranged in a sequence of platform lectures, poster presentations and discussion sessions so that all the participants had opportunities to discuss the subjects presented. Most of the participants contributed a chapter to this volume. We would like to express our regret to many other scientists including Professor King's friends, colleagues and students who could not attend due to various reasons.

Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive advances in 'mitochondrial physiology'-the role of the mitochondria in the life and death of the cell. Covering mitochondria, bacteria and chloroplasts, the fourth edition of Bioenergetics provides a clear and comprehensive account of the chemiosmotic theory and its many applications. The figures have been carefully designed to be memorable and to convey the key functional and mechanistic information. Written for students and researchers alike, Bioenergetics is the most well-known, current and respected text on chemiosmotic theory and membrane bioenergetics available. BMA Medical Book Awards 2014-Highly Commended, Basic and Clinical Sciences,2014,British Medical Association Chapters are now divided between three interlocking sections: basic principles, structures and mechanisms, and mitochondrial physiology. Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins. Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging. Offers readers clear, visual representation of structural concepts through full colour figures throughout the book.

Bioenergetics 2 aims to clarify topics such as the thermodynamics of bioenergetic processes and the stoichiometries of energy coupling reactions. The book discusses chemiosmotic energy transduction; ion transport across energy-conserving membranes; and quantitative bioenergenetics as the measurement of driving forces. The text also describes the chemiosmotic proton circuit; the respiratory chain; the photosynthetic generators of protonmotive force; and the ATP synthase. The secondary transport of products across the membrane, as well as the structures of the bacterial photosynthetic reaction center and bacteriorhodopsin are also considered. Biochemists will find the book invaluable.

Revised and updated to include the many developments that have taken place in bioenergetics, this text covers the structures of key membrane proteins involved in bioenergetics and mitochondrial physiology.

This book describes a half century of research on cellular membrane transport and on metabolic energy capture and utilization. During this time-which begins in the late 1930s-the effort and imagination of various scientists overthrew reigning formulations, created novel explanatory models, and unified previously distinct experimental fields. My primary goal is to display the course of that research, showing how new experiments defined novel entities and processes, and how an encompassing field, bioenergetics, then emerged. A secondary goal is to present examples of mainstream biological research that illustrate how experimental results-seen as refutations, confirmations, and elabora tions-can sway opinion toward a solid consensus. This interpretation differs from the currently fashionable view of some commentators that stresses instead the central roles of power, prestige, gender, class, and ethnicity. In any case, the scien tific practices exhibited here deserve proper philosophical scrutiny. Although con straints of space have squeezed any analysis from this draft, brief mention of salient issues does appear in relevant chapters and in the final conclusions. (Oddly, histori ans and philosophers seem reluctant to deal with this science. Those who do consider biological topics tend to focus on the theory of evolution, even though the bulk of biological research in this century, in terms of papers published and technology influenced, has dealt not with evolution per se but with what may be termed physiology and biochemistry. And these endeavors, which are the aims, efforts, and accomplishments of the vast majority of biologists, have been largely ignored.