Translational Oral Health Research

This book is the first to be devoted to translational research – which aims to expedite the transfer of knowledge gained in the lab to clinical practice – within the field of oral health. It is examined how basic sciences and basic research are providing new methods and materials that will enable clinicians to treat patients more effectively. Readers will gain a translational perspective on a variety of oral conditions and related systemic diseases. Individual chapters are devoted to such topics as dental biomaterials, implants, and tissue engineering. The importance of evidence-based research and the roles and comparative value of preclinical and clinical trials are also highlighted. Knowledge of translational and clinical research is essential in understanding how new inventions and developments are being accomplished, and what regulations and guidelines need to be taken into account when planning studies, and not forgetting the ethical aspects of any research. Translational Oral Health Research is the first book to be devoted entirely to the subject, and it will be of interest to both researchers and practitioners.

Clinical Research in Oral Health surveys the essentials of clinical research in oral health, anchoring these principles within the specific context of the oral health arena. Addressing research questions exclusively applicable to dentistry and oral health, the book thoroughly illustrates the principles and practice of oral health clinical research. Clinical Research in Oral Health also clarifies the framework of regulatory issues and presents emerging concepts in clinical translation, relating the research principles to clinical improvement.

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

As a result of scientific advancements and changing demographics in the United States and around the world, people of all ethnic groups and nationalities are retaining their teeth longer. Todays oral health professionals must therefore be prepared to make educated and scientifically-reasoned choices addressing a wide range of oral diseases for patients of all ages, and for ambulatory as well as non-ambulatory patients across all demographic profiles. As the first text of its kind, Oral Health Epidemiology: Principles and Practice explores the full spectrum of epidemiological and translational clinical research including fundamental mechanisms of human disease, therapeutic intervention, clinical trials, and oral epidemiology. Topics that are unique to oral health, such as the frequent use of split-mouth design on oral research, crossover techniques and clustered nature of caries, periodontal and other dental disease data, are all thoroughly addressed. Key Features: Thoroughly explores clinicaltranslational research and the special needs of oral health study designs that are applicable across all specialties in dentistry. Serves as a basic guide to advanced techniques such as bioinformatics, genetics, molecular biology, and computer simulation, biostatistics that are now used regularly in oral health research. Prepares the reader to design studies, translate the findings to practice, and conduct logical critique of scientific literature.

"Paediatric Dentistry combines both the theoretical and practical aspects of paediatric dentistry for the child up to age 16, from all dental specialities."--Publisher.

This report is the twelfth assessment of the National Institutes of Health National Research Service Awards program. The research training needs of the country in basic biomedical, clinical, and behavioral and social sciences are considered. Also included are the training needs of oral health, nursing, and health services research. The report has been broadly constructed to take into account the rapidly evolving national and international health care needs. The past and present are analyzed, and predictions with regard to future needs are presented.

This book introduces early career students and researchers to a complete update on various aspects of major methods and techniques used in the field of implant dentistry and guided-bone-regeneration research. This unique book guides the reader through each aspect in great detail, from basic research approaches such as surface-characterization techniques, in vitro experiments, and ethics and regulations for the use of laboratory animals to the application of different animal models in implant dentistry and bone-regeneration research, imaging techniques, computer finite element models, biomechanical methods, analytical methods for the boneimplant interface, and finally to conducting clinical research.