Reconceptualizing Schizophrenia

This volume presents a novel, international research study that reconceptualizes schizophrenia through an investigation of ways in which the first-hand experiences of those with a diagnosis differ from conventional diagnostic definitions. Offering insight into the history of psychiatric taxonomies in general and the invention of the schizophrenia diagnosis in particular, Reconceptualizing Schizophrenia maps the emergence of uncertainties about the empirical and conceptual status of contemporary diagnostic systems. Particular focus is given to the heterogeneity problem, or the problem of wide empirical variation within and between disorder categories. At the heart of this book are interviews with mental health service users with psychotic-disorder diagnoses in New York City and Jerusalem. Through a detailed portrait of their existential and socio-institutional worlds, the book unveils a way of being-in-the-world characterized by the experience of feeling profoundly vulnerable and unsafe in an inhospitable world as well as foreclosed from belonging to one or more human communities. As this psychological portrait of urhomelessness unfolds, the reader becomes slowly aware of the relationships between psychotic experiences – often thought to be bizarre or ‘un-understandable’ – and the timeless ways in which all humans seek to dwell in the world. Making an important contribution to the phenomenological-existential literature on psychosis, and demonstrating interdisciplinary and transcultural approaches to understanding anomalous experiences, this volume will be of great interest to researchers and scholars of transcultural psychiatry, clinical psychology, and critical theory.

This volume presents a novel, international research study that reconceptualizes schizophrenia through an investigation of ways in which the first-hand, lived experiences of those with a diagnosis differ from conventional diagnostic definitions. Offering insight into the history of psychiatric taxonomies in general and the invention of the schizophrenia diagnosis in particular, Reconceptualizing Schizophrenia maps the emergence of uncertainties about the empirical and conceptual status of contemporary diagnostic systems. Particular focus is given to the heterogeneity problem, or the problem of wide empirical variation within and between disorder categories. At the heart of this book are interviews with mental health service users with psychotic-disorder diagnoses in New York City and Jerusalem. Through a detailed portrait of their existential and socio-institutional worlds, the book unveils a way of being-in-the-world characterized by the experience of feeling profoundly vulnerable and unsafe in an inhospitable world, as well as foreclosed from belonging to one or more human communities. As this psychological portrait of urhomelessness unfolds, the reader becomes slowly aware of the relationships between psychotic experiences--often thought to be bizarre or 'un-understandable'--and the timeless ways in which all humans seek to dwell in the world. Making an important contribution to the phenomenological-existential literature on psychosis, and demonstrating interdisciplinary and transcultural approaches to understanding anomalous experiences, this volume will be of great interest to researchers and scholars of transcultural psychiatry, clinical psychology, and critical theory.

The Digital Age has changed everything. Mental illness is nothing like what it was even twenty years ago. Since the advent of the Internet, suicide rates have soared. Depression has become the single most debilitating disease in the world. The majority of people who go to their doctor, to an emergency department, and to urgent care have no discernible physical disease. Roughly half of all adults in Western countries struggle with at least one addiction. We now live in a 24/7 miasma of media bombardment, of neuro-saturation, and of mental exhaustion. Technology has obliterated the human mind’s ability to keep up, and in this brave new world it is time for an honest and forthright reassessment of both mental illness and mental wellness. This book elegantly describes how we got to this point, the culmination of different historical perspectives on mental illness, and the evolution of the digital disorders of our time. It offers a reconsideration of normal versus pathological, and the possibility and desirability of achieving mental wellness in a digital environment.

This comprehensive book explains the importance of imaging techniques in exploring and understanding the role of brain abnormalities in schizophrenia. The findings obtained using individual imaging modalities and their biological interpretation are reviewed in detail, and updates are provided on methodology, testable hypotheses, limitations, and new directions for research. The coverage also includes important recent applications of neuroimaging to schizophrenia, for example in relation to non-pharmacological interventions, brain development, genetics, and prediction of treatment response and outcome. Written by world renowned experts in the field, the book will be invaluable to all who wish to learn about the newest and most important developments in neuroimaging research in schizophrenia, how these developments relate to the last 30 years of research, and how they can be leveraged to bring us closer to a cure for this devastating disorder. Neuroimaging in Schizophrenia will assist clinicians in navigating what is an extremely complex field and will be a source of insight and stimulation for researchers.

A neuroscientist explores the biological bases of schizophrenia and tells the heartbreaking story of his own brother’s battle with the disease. When bright lives are derailed by schizophrenia, bewildered and anxious families struggle to help, and to cope, even as scientists search for causes and treatments that prove elusive. Painful and often misunderstood, schizophrenia profoundly affects people who have the disease and their loved ones. Here Ronald Chase, an accomplished biologist, sets out to discover the facts about the disease and better understand what happened to his older brother, Jim, who developed schizophrenia as a young adult. Chase’s account alternates between a fiercely loyal and honest memoir and rigorous scientific exploration. He finds scientific answers to deeply personal questions about the course of his brother’s illness. He describes psychiatric practice from the 1950s—when electroconvulsive shock therapy was common and the use of antipsychotic medications was in its infancy—to the development of newer treatments in the 1990s. Current medical and scientific research increases our understanding of genetic and environmental causes of the disease. Chase also explores the stigma of mental illness, the evolution of schizophrenia, the paradox of its persistence despite low reproduction rates in persons with the disease, and the human stories behind death statistics. With the author’s intimate knowledge of the suffering caused by this disease, Schizophrenia emphasizes research strategies, the importance of sound scientific approaches, and the challenges that remain. “A rare combination of family memoir and accessible explanation of the neuroscience, genetics, and the epidemiology of schizophrenia. I simply love this book.” —Patrick Tracey, PsychCentral

Schizophrenia is one of the most complex and disabling diseases to affect mankind. Relatively little is known about its nature and its origins, and available treatments are inadequate for most patients. As a result, there are inevitable controversies about what causes it, how to diagnose it, and how best to treat it. However, in the past decade, there has been an explosion of new research, with dramatic discoveries involving genetic etiology and epidemiological risk factors. There has also been a catalog of new drugs coming to market, and controversy about the relative advantages and disadvantages of newer compared with older therapies. In addition, developing technologies in genomics, molecular biology and neuroimaging provide streams of new information. This book represents a definitive, essential, and up-to-date reference text on schizophrenia. It extensively and critically digests and clarifies recent advances and places them within a clinical context. The Editors (one American and one British), highly respected clinical psychiatrists and researchers and acknowledged experts on schizophrenia, have again assembled an outstanding group of contributors from the USA, UK, Europe and Australia, It will be of value to practising psychiatrists and to trainees, as well as to clinical and neuroscience researchers interested in keeping up with this field or coming into it. The book consists of four sections: descriptive aspects, biological aspects, physical treatments, and psychological and social aspects. It reviews the theoretical controversies over symptomatology, classification and aetiology (particularly pertinent as DSM-V is being developed), the relationship of schizophrenia to the other psychoses, the significance of positive and negative symptoms and pre-morbid personality. It describes a variety of approaches to integrating the vast research data about schizophrenia, including neurodevelopmental, genetic, pharmacological, brain imaging and psychological findings. The biological treatment section reviews the comparative efficacy of various drugs, the management of drug-resistant patients and both neurological and metabolic complications. The final section looks at psychological therapies, social outcomes, and the economics of schizophrenia. Highly Commended in the Psychiatry section of the 2012 BMA Book Awards.

This book contains concrete and step by step information with many practical examples. It is in line with the most actual international empirical findings about schizophrenia and contains the most updated therapy approach being available currently. The techniques and exercises (partly computer-based) are described in detail. Case examples point out specific therapeutic situations and teach the therapist how to cope with complicated group and individual demands. Assessment for patient selection, differential indication and therapy control within a multi-dimensional treatment and rehabilitation system are discussed. INT was evaluated successfully in an international randomised multi-centre study. In the meantime it is implemented in many clinical settings in German speaking countries. Integrated Neurocognitive Therapy (INT) is a cognitive remediation therapy approach. INT is the first treatment manual comprising all MATRICS areas (Measurement and Treatment Research to Improve Cognition in Schizophrenia). The NIMH (National Institute of Mental Health, USA) initiated this MATRICS initiative. MATRICS defines 11 neurocognitive and social cognitive areas of functioning being relevant for patients with schizophrenia. The improvement of these areas in a group therapy is the main goal of INT. INT is based on IPT (Integrated Psychological Therapy, Roder et al 2010). It is a resource and a recovery oriented intervention to enhance also therapy motivation and self-esteem and to reduce negative symptoms. Therapy focuses especially on group processes and the exercises augment transfer and generalisation to daily life. As a meta goal INT intends to amend life quality and the reintegration of the patients in the community. The presented manual offers the clinicians a practically orientated guide for carrying out INT.

One of the first major theoretical reviews of schizophrenia since the publication of the 5th edition of the APA’s Diagnostic and Statistical Manual, the DSM-5, this volume is a landmark in the history of schizophrenia research. It assembles recent groundbreaking developments in research on schizophrenia and reaffirms its central place in the mental health research agenda. Significantly, this volume reflects the paradigmatic shift in schizophrenia research applied in parallel to new approaches in psychiatric diagnosis. New models and findings from across disciplines in recent years reflect a new and greater understanding of the workings of the brain, which, in turn, helps develop our knowledge of the neuro and psychological processes in schizophrenia. Consequently, this volume illustrates a historical convergence of psychology, psychopathology and the neurosciences in schizophrenia. World-renowned leaders of the schizophrenia research community in fields such as neuroscience, p sychiatry, neuropsychology, and clinical psychology offer clear suggestions for further advances in psychological and medical interventions, assessment, prevention strategies, and research. And in keeping with other titles in the Nebraska Symposium on Motivation series, these papers are noteworthy for their depth of detail, scientific rigor, and clinical relevance. Included among the topics: Cognitive organization as a dimension of individual differences and psychopathology. Neurodevelopmental genomic strategies in the study of the psychosis spectrum. Multimodal brain and behavior indices of psychosis risk. The NIMH Research Domain Criteria Project: new approaches to classifying psychotic spectrum disorders. The Neuropsychopathology of Schizophrenia is one of the most forward-thinking and engaging treatments of the field in recent years, and is an i ndispensable text for all researchers, academics, and clinicians who treat or study mental illness, especially psychiatrists, psychologists, mental health practitioners, and neuroscientists specializing in schizophrenia.